Chinese Medicine 2019
A pair of new enantiomers of xanthones from the stems and leaves of Cratoxylum cochinchinense.
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Methods
The structures of new compounds 1a and 1b were elucidated mainly through comprehensive NMR and MS spectroscopic data, and their absolute configurations were determined by the comparison of the experimental and calculated electronic circular dichroism.Results
A pair of new xanthone enantiomers, (+)- and (-)-cracochinxanthone A (1a and 1b), along with thirty known analogues (2-31), were isolated from extracts of the stems and leaves of C. cochinchinense. Preliminary biological assay of some isolates against HL-60, PC-3, and MDA-MB-231 cancer cell lines.