Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 2005-Apr
[Effects of 5F from Pteri semipinnata on the expression of ETS-1 mRNA and VEGF protein of highly metastatic ovarian carcinoma HO-8910PM cells].
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OBJECTIVE
To study the effect of 5F from Pteri semipinnata L. on the expression of ETS-1 mRNA and VEGF protein, and to investigate the antitumor mechanisms of 5F from Pteri semipinnata L.
METHODS
RT-PCR assay was used to assess the expression level of ETS-1 mRNA. The expression level of VEGF protein was assessed by Western blot analysis.
RESULTS
The expression level of of VEGF protein obviously decreased in HO-8910PM cells treated with 25 to approximately 100 micromol/L 5F for 24 hours. 5F significantly down-regulated the expression of ETS-1 mRNA.
CONCLUSIONS
The antitumor activity of 5F from Pteri semipinnata L is involved in the expression of ETS-1 mRNA and VEGF protein.
