Effects of atropine and neostigmine on receptor interaction at the neuromuscular junction.
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Rats treated chronically with atropine or atropine and neostigmine showed marked alterations in the responsiveness of receptors at the neuromuscular junction. Receptors in the phrenic nerve-hemidiaphragm interacting with d-tubocurarine were unaffected by atropine but exhibited a supersensitivity after neostigmine administration. Succinylcholine-sensitive sites developed a subsensitivity with both atropine and neostigmine treatment. Acetylcholine-induced contractures in the denervated hemidiaphragm showed a hypersensitivity after both drug administrations, but responses to carbamylcholine were unaffected. It is suggested that there exists a heterogeneous population of receptors at the mammalian neuromuscular junction who can be identified by their responses to the effects of chronic drug application.
