Effects of tamoxifen on urinary incontinence: Case report and review of literature.
Từ khóa
trừu tượng
BACKGROUND
Tamoxifen has been used in women with hormone receptor-positive breast cancer and has been shown to successfully reduce both recurrence and mortality. On the contrary, long-term use of tamoxifen has hormone-related urogenital side effects which decrease the quality of life of the patients.
UNASSIGNED
In this case report, we present a breast cancer patient receiving tamoxifen who developed urinary incontinence; we discuss the effects of tamoxifen on urinary incontinence, which decreases quality of life of the patients who were evaluated in our clinic.
UNASSIGNED
Breast cancer, urinary incontinence.
METHODS
Temporarily discontinuing tamoxifen.
RESULTS
Urinary incontinence resolved.
CONCLUSIONS
Based on the case we reported and literature, estrogen can cause a dose-dependent increase in incontinence, but more preclinical and clinical studies of both estrogen and SERMs are needed to support this notion; given the fact that some small-scale clinical studies have not proven a direct relationship between tamoxifen and urinary incontinence. We suggest that clinicians faced with the issue should temporarily stop usage of the drug once the complaint of urinary incontinence arises.
