Efficacy and safety of Derris scandens Benth extracts in patients with knee osteoarthritis.
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OBJECTIVE
The objectives of this study were to determine the efficacy and safety of Derris scandens Benth extracts in pain reduction and functional improvement in patients with knee osteoarthritis (OA).
METHODS
This was a prospective, randomized, controlled trial, single-blinded (assessor).
METHODS
The study was conducted at the Rehabilitation Medicine Department, Siriraj Hospital.
METHODS
One hundred and seven (107) patients with primary OA knee who had pain score of ≥ 5 were recruited.
METHODS
Patients were randomized to receive naproxen 500 mg/day or Derris 800 mg/day for 4 weeks.
METHODS
Western Ontario McMaster Osteoarthritis Index (WOMAC) scores and 6-minute walking distance were the outcome measurements.
RESULTS
Fifty-five (55) and 52 patients were randomized to Derris and naproxen groups, respectively. The mean differences of all WOMAC scores between 2 groups at week 4 adjusted by week 0 were within ± 1 point. The mean scores of the aforementioned outcomes at weeks 0, 2, and 4 were significantly improved compared to the baseline values. There was no difference of WOMAC scores between groups. The gastrointestinal irritation and dyspepsia were observed more often in the naproxen than in the Derris group.
CONCLUSIONS
Derris scandens Benth extracts were efficacious and safe for the treatment of knee OA.
