[Influence of cookies with a modified carbohydrate profile on postprandial glycemia in patients with type 2 diabetes].

The aim of the study was assessment of influence of cookies with a modified carbohydrate profile on postprandial glycemia in patients with type 2 diabetes. The study included 20 patients 35–69 years old, with type 2 diabetes and obesity II–III degrees (BMI=40.2±1.1 kg/m2) treated with standard hypoglycemic therapy. At the time of the initial evaluation all patients were determined at the stage of metabolic subcompensation: glucose basal level in venous blood was 6.8±0.3 mmol/l; in capillary blood – 6.5±0.5 mmol/l; the level of glycated hemoglobin – 7.2±0.2%. Glucose blood plasma level on an empty stomach and within 3 hours after the consumption of biscuits with modified carbohydrate profile (25 g digestible carbohydrates) and wheat bread containing 25 g digestible carbohydrates (control) was determined. Calculation of the area under the glycemic curve was conducted by standard technique. Portability of cookies with a modified carbohydrate profile (replacement of wheat flour to the mixture of buckwheat, oat and barley flour and the use of maltitol) was good, with no side effects or signs of intolerance were observed. It has been shown that consumption of biscuits with a modified carbohydrate profile was accompanied by a significantly smaller rise in blood glucose level after 30 min from the start of the study, compared with the standard food load (an average of 19.1% and 42.4%, respectively, from baseline, p<0.05). After 120 and 180 min after the test food loads glycemia changed equally, without significant differences between foodstuffs. Area under the glycemic curve in the consumption of cookies with a modified carbohydrate profile was significantly less than under the standard food load (184.6±16.7 vs. 236.9±21.2 mmol/l×min, p<0.05). Consumption of biscuits with modified carbohydrate profile was accompanied by less severe postprandial glycemic response in patients with type 2 diabetes in comparison with that at a standard load food containing 25 g digestible carbohydrates.