Fitoterapia 2018-Sep
Iridal-type triterpenoids with anti-HBV activity from Iris confusa.
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Five new iridal-type triterpenoids, named as spirioiridoconfal A-C (1-3), isobelamcandal (4) and 17-hydroxyl-27-ene-iridal (5), along with one known compound (6) were isolated from the whole plant of Iris confusa. Their structures were determined by extensive spectroscopic analyses. Compounds 3 and 6 showed moderate activity against HBV DNA replication in vitro with the IC50 value at 84.6 ± 24.9 (SI = 2.1) and 58.6 ± 6.1 (SI = 12.7) μM relatively.