Preliminary research concerning antinociceptive and antiinflammatory effects of two extracts from Glinus oppositifolius (L.) Aug. DC.
Từ khóa
trừu tượng
In Mali Glinus oppositifolius (L.) Aug. DC. (Aizoaceae) is used to treat inflammations and joint pains.
OBJECTIVE
The present study was designed to evaluate the antinociceptive and anti-inflammatory effects of the aqueous and ethanol extracts obtained from the aerial parts of the plant.
METHODS
The aqueous and ethanol extracts (G-A1 and G-E1, respectively) were studied regarding their acute toxicity. The extracts were further evaluated in different models using nociceptive (chemical, thermal, mechanical) and inflammatory stimuli. Experimental protocol was implemented according to international regulations in animal experiments.
CONCLUSIONS
No acute toxicity was noticed for these two extracts. ED50 (mg/kg bw) values were determined in different nociception models: the constrictive abdominal response test (G-A1: 229.00 +/- 53.30; G-E1: 146.38 +/- 31.75), hot plate test (G-A1: 278.59 +/- 73.00; G-E1: 383.52 +/- 89.69), Randall-Selitto test (G-A1: 207.14 +/- 26.15), evaluation of the inflammatory edema test (G-A1: 228.31 +/- 13.84; G-E1: 62.55 +/- 89.69).
CONCLUSIONS
The results of the inflammatory nociception studies show that G-E1 extract had a higher potency than G-A1 extract in the constrictive abdominal response test. Also, for the same level of anti-inflammatory activity, G-E1 extract was more potent than G-A1 extract. These results encourage further studies to separate, isolate and identify the phytochemicals responsible for the analgesic and anti-inflammatory effects.
