[Stereological ultrastructural study of myocardial atrophy in hypokinesia].
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trừu tượng
The myocardium of Wistar rats immobilized for 5, 15 and 30 days was examined by morphometry and stereological methods for evaluating the volumetric and surface density of myofibrils, mitochondria, T system, sarcoplasmic reticulum and for the measurement of the volumetric ratio of different ultrastructures to the density of myofibrils and the surface-volumetric ratio of the main organelles of the cardiomyocyte. Myocardial atrophy was shown to develop in the course of hypokinesia. The 30-day hypokinesia entailed changes in ultrastructural organization of cardiomyocytes, attesting to the tension of intracellular systems responsible for energy supply, of ionic membrane transport and the contractile apparatus.