Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1992-May
The involvement of collagenase in the necrosis induced by the bites of some spiders.
Chỉ người dùng đã đăng ký mới có thể dịch các bài báo
Đăng nhập Đăng ký
Liên kết được lưu vào khay nhớ tạm
Từ khóa
trừu tượng
1. The midgut extracts of 13 Australian spider species produced cellular disruption in mouse skin in tissue culture conditions. 2. Microbial collagenase and the venoms of some of these species had similar effects. 3. Five venoms also caused severe dermonecrosis in living mice. 4. Pre-mixing the venoms with L-cysteine caused complete in vivo and partial in vitro inhibition of their effects. 5. It was concluded that collagenase is a major factor in the aetiology of necrotic arachnidism.