[The membrane-protective effect of carnosine in the post-resuscitation period after acute lethal blood loss].
Từ khóa
trừu tượng
Activation of serum enzymes in male rats was detected during the postresuscitation period after 4-6-min clinical death as a result of membrane destruction. Increase in the rate of lipid peroxidation and impairments of energy metabolism in the myocardium were responsible for destruction of cardiomyocyte biomembranes. Administration of carnosine (25 mg/kg body weight) simultaneously with compensation for blood loss obviated the membrane lipid bilayer destruction and contributed to the development of the optimal conditions for membrane-bound enzymes.