All patients will be assigned intravenous alpha lipoic acid 600mg within 24 hours of symptom onset. Patients will receive intravenous alpha lipoic acid 600mg/day for one week, followed by an oral pill of alpha lipoic acid 600mg/day for three months.

All patients will receive intravenous normal saline within 24 hours of symptom onset.

Stroke, Ischemic

alpha lipoic acid

Saline

Chonnam National University Hospital

Impact of Lipoic Acid Use on Stroke Outcome After Reperfusion Therapy in Patients With Diabetes (IMPORTANT)

Impact of Lipoic Acid Use on Stroke Outcome After Reperfusion Therapy in Patients With Diabetes

The modified Rankin Scale (mRS) consists of 7 levels, ranging from perfect health without symptoms (mRS score 0) to death (mRS score 6). We defined functional independence as mRS scores of 0-2 at 3 months after stroke.

Hemorrhagic transformation within 1 week, Brain edema at 1 week after stroke

early neurological deterioration is defined as an increase of ≥1 point in motor power or an increase of ≥2 points in the total NIHSS score within 2 weeks

Intracranial and extracranial bleeding within 3 months

IPD will be shared with other researchers.

Kangho Choi

Study Director

Chosun University Hospital

Chonbuk National University Hospital

Wonkwang University Hospital

Subjects will be tested on one day. Baseline testing will take place and will be followed by oral antioxidant cocktail intake. Oral antioxidant cocktail testing will take place ~2 hours after antioxidant intake.
During baseline testing, no supplement or placebo intake will be used.

Subjects will be tested on one day. Baseline testing will take place and will be followed by oral antioxidant cocktail intake. Oral antioxidant cocktail testing will take place ~2 hours after antioxidant intake.
Dose 1:(immediately after baseline) 300 mg alpha-lipoic acid, 500 mg vitamin C, 200 IU vitamin E Dose 2: (30 minutes after dose 1) 300 mg alpha-lipoic acid, 500 mg vitamin C, 400 IU vitamin E

Cardiovascular Diseases

Oral antioxidant cocktail intake will occur after baseline measurements:
Dose 1 (immediately after baseline testing): 300 mg alpha-lipoic acid, 500 mg vitamin C, 200 IU vitamin E Dose 2 (30 minutes after Dose 1): 300 mg alpha-lipoic acid, 500 mg vitamin C, 400 IU vitamin E

Oral antioxidant cocktail

No oral antioxidant cocktail intake or placebo intake will occur prior to baseline measurements

Baseline

Effects of Oral Antioxidant Cocktail in Cardiovascular Disease Patients

Effects of Oral Antioxidant Cocktail on Vascular Function and Blood Flow in Cardiovascular Disease Patients

Flow-mediated dilation will be used to measure endothelial function in the brachial artery. This will be done pre- and post-antioxidant intake.

Brachial-to-ankle pulse-wave velocity and carotid-to-femoral pulse-wave velocity will be used to measure arterial stiffness. This will be done pre- and post-antioxidant intake.

Doppler ultrasound will be used to measure blood flow in the femoral and popliteal arteries. This will be done pre- and post-antioxidant intake.

10 mL of blood will be drawn from an antecubital vein pre- and post-antioxidant intake.

Heart rate variability will be measured to determine autonomic function. This will be done pre- and post-antioxidant intake.

Muscle tissue oxygenation will be assessed using near-infrared spectroscopy (NIRS) during a maximal walking protocol pre- and post-antioxidant intake.

Physical walking capacity will be measured using the Gardner treadmill protocol pre- and post-antioxidant intake.

alpha lipoic acid/tai biến mạch máu não

Impact of Lipoic Acid Use on Stroke Outcome After Reperfusion Therapy in Patients With Diabetes (IMPORTANT)

Effects of Oral Antioxidant Cocktail in Cardiovascular Disease Patients

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