Cases (incident patients with a diagnosis of primary sarcoma and histologically confirmed by an expert pathologist of the RRePS or ResOs networks in the 15 districts of France participating to this study) Environmental, occupational and lifestyle-related exposures

Subjects never diagnosed with a primary sarcoma and individually-matched by sex, age (5-years group), and districts of residence and randomly selected from electoral list.
Environmental, occupational and lifestyle-related exposures

Each participant will be asked to provide a salivary sample in order to obtain germline DNA. Salivary samples will be collected by the subjects themselves under instructions from the CRA, using DNA Genotek Oragene 575 collection kit. After collection, samples will be sent at the Biological Resources Center of the Bordeaux hospital university center "Bordeaux Biothèque Santé" for storage.

Sarcoma

Environmental Exposure

Occupational Exposure

Life Style

A standardized questionnaire will be administered by a trained interviewer in order to gather information about occupational and residential history, demographic and socioeconomic characteristics and lifestyle factors. At the end of the interview, a saliva sample will be systematically proposed

Environmental, occupational and lifestyle-related exposures

CHRU

Institut Bergonié

Centre François Baclesse

Centre Oscar Lambret

CHU Dupuytren

Centre Léon Bérard

Institut régional du Cancer Montpellier

Institut Gustave Roussy

Etiosarc: Environmental Aetiology of Sarcomas From a Multicenter French Population-based Case-control Study Among Adults

Etiosarc: Study of the Environmental Aetiology (Environment, Occupations and Lifestyle) of Sarcomas (Soft Tissue, Visceral and Bone) From a Multicenter French Population-based Case-control Study Among Adults.

The relationship between case/control status and each exposure variable will be estimated by odds ratios and their 95% confidence intervals using conditional logistic regression models.

Anonymized individual participant data for both cases and controls will be made available under request to the principal investigator

Institut National de la Santé Et de la Recherche Médicale, France

Osteomyelitis

UT Southwestern Medical Center

Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis (PCT)

Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis

Serial measurements of procalcitonin at Baseline, Week 3 and Week 6.

University of Texas Southwestern Medical Center

Electrical stimulation device worn on the leg delivering a dose of 50 volts.

Electrical stimulation device worn on the leg and programmed to deliver no stimulation.

Diabetic Peripheral Neuropathy

An electrical stimulation device worn on a band around the leg. This device was determined to be non-significant risk by the FDA.

SENSUS Pain Management System

UT Southwestern Medical Center at Dallas

Electrical Stimulation for Improving Balance in Diabetes

Postural control changes will be measured using the BalanSense device in subjects assigned to use the active Electrical Stimulation (intervention group) and subjects assigned to non‐functional stimulator (sham group). Balance will be assessed for both groups at baseline and at each follow-up visit, weeks 2, 4, 6 and 8. Static balance and postural compensatory strategy will be assessed using the body worn sensor technology.

We will evaluate Vibration Perception Threshold (VPT) Testing to evaluate large fiber neuropathy at weeks 2, 4, 6 and 8.

8 sensors will be attached to the legs and lower back using comfortable straps and will be asked to walk 20 meters on a flat surface, two times. A third 20 meter walk will be performed with an additional distractive cognitive task (counting -1). The 4th test will be fast walking. Walking performance (e.g., speed, cadence, and stability) and spatio-temporal parameters of gait (e.g., velocity, stride time, gait inter-cycle variability, double support, and gait initiation) will be measured at weeks 2, 4, 6 and 8.

Pain will be assessed using a Visual Analogue Scale (completed by the subject) at weeks 2, 4, 6 and 8.

Spontaneous daily physical activity will be monitored in home environment for 2 days using PAMSysTM

Quality of life will be assessed using the SF-12 questionnaire to be completed by the subject.

The participant will receive a log and agree to call the study overseer in the event of a fall during the 8 weeks study period.

bone neoplasms/nicotine

Etiosarc: Environmental Aetiology of Sarcomas From a Multicenter French Population-based Case-control Study Among Adults

Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis (PCT)

Electrical Stimulation for Improving Balance in Diabetes

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