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Endometriosis is a gynecologic disease characterized by the ectopic presence of endometrial tissue on organs within the peritoneal cavity, causing debilitating abdominal pain and infertility. Current treatments alleviate moderate pain symptoms associated with the disorder but exhibit limited ability
OBJECTIVE
To explore endometriosis-related molecules in patients with use of differential display analysis.
METHODS
Prospective study.
METHODS
Nagoya City University Medical School, Nagoya, Japan.
METHODS
Women with endometriosis (n = 27) and without endometriosis (n = 21).
METHODS
Surgery was
OBJECTIVE
To determine whether expression of secretory leukocyte protease inhibitor is affected in tissue and peritoneal fluid of women with ovarian endometriomas treated with GnRH analogues.
METHODS
In 32 women with endometriomas (17 untreated and 15 treated with GnRH analogue) and 21 with ovarian
BACKGROUND
Recent data indicate the implication of an IGF/IGFBP/protease system in the development of ectopic implants of endometrium (endometriosis) in the pelvic cavity.
METHODS
We characterized mitogens and protease(s) against IGFBP-3 in the peritoneal fluid of women with or without endometriosis
Secretory leukocyte protease inhibitor (SLPI) is a potent inhibitor of human leukocyte elastase. We investigated whether SLPI was present in the peritoneal fluid of women with endometriosis and to clarify the role of SLPI in the pathogenesis of endometriosis. Western blot analyses revealed that SLPI
This study was undertaken to determine whether women with endometriosis have altered protein, progesterone (P), and protease inhibitor concentrations in their uterine fluid and peritoneal fluid (PF) compared with controls at different phases of the menstrual cycle. Uterine flushings (UFs), PF, and
The present study was undertaken to investigate the function of protease-activated receptor (PAR) in endometriotic lesions using a mouse model of endometriosis. Unilateral ovariectomy (uOVX) was performed on female nude mice followed by intraperitoneal transplantation of a suspension mixture of
Endometriosis is known to be associated with local inflammatory reactions. Given the emerging concept of thrombin and its specific receptor, protease-activated receptor 1 (PAR1), as important players in inflammation and cell proliferation, we investigated whether thrombin and PAR1 might be involved
OBJECTIVE
Protease-activated receptor 2 plays an important role in the pathogenesis of endometriosis. We studied the effect of ENMD-1068, a protease-activated receptor 2 antagonist, on the development of endometriosis in a noninvasive fluorescent mouse model.
METHODS
A red fluorescent
OBJECTIVE
To compare levels of insulin-like growth factor (IGF) components in the peritoneal fluid of patients with and without endometriosis.
METHODS
Patients with endometriosis were compared with control patients.
METHODS
Seoul National University Hospital, Korea.
METHODS
Forty-three patients with
Endometriosis-associated infertility manifests itself via multiple, poorly understood mechanisms. Our goal was to characterize signaling pathways, between peritoneal endometriotic lesions and the ovary, leading to failed ovulation. Genome-wide microarray analysis comparing ovarian tissue from an in
As principal degrading enzymes of the extracellular matrix, metalloproteinases (MPs) contribute to various pathologies and represent a family of promising drug targets and biomarker candidates. However, multiple proteases and endogenous inhibitors interact to govern MP activity, often leading to
Endometriosis is a continuous and progressive disease with a poorly understood aetiology, pathophysiology and natural history. This study evaluated the histological differences between eutopic and ectopic endometria (abdominal wall endometriosis) and the expression of mast cell proteases (tryptase
OBJECTIVE
To examine the regulation and the function of activin-A in stromal cells derived from endometrioma.
METHODS
Molecular studies.
METHODS
University research laboratory.
METHODS
Endometrioma stromal cells (EoSC) were obtained from 28 patients with ovarian endometrioma undergoing
OBJECTIVE
Little is known about the roles of TF and PAR-2 in endometriosis. This article investigated the expression of TF and PAR-2 in ectopic and eutopic endometrium with endometriosis and their relationship with the menstrual cycle.
METHODS
Ectopic and eutopic endometrium tissues from 42 women