(Digital chromoendoscopy with Optical Enhancement and without magnification; Digital chromoendoscopy with Optical Enhancement and with magnification; optical magnification without Digital chromoendoscopy: Optical Enhancement) Patients with reflux symptoms, without endoscopic lesions on the upper endoscopy with high definition white light or I-Scan and a positive ph-impedanciometry for reflux

(Digital chromoendoscopy with Optical Enhancement and without magnification; Digital chromoendoscopy with Optical Enhancement and with magnification; optical magnification without Digital chromoendoscopy: Optical Enhancement) Patients with reflux symptoms, without endoscopic lesions on the upper endoscopy with high definition white light or I-Scan and a negative ph-impedanciometry for reflux

Non Erosive Reflux Disease

GERD

A endoscopic visualization of the mucosa using the pre-processor filter called Optical enhancement (Pentax Video Processor EPK-i7010; HOYA Co. Tokyo, Japan)

Optical Enhancement

A endoscopic visualization of the mucosa using the pre-processor filter called Optical enhancement associated with an optical magnification using the scope called magniview (PENTAX Medical EG-2990Zi)

Optical Enhancement with optical magnification

A endoscopic visualization of the mucosa using optical magnification without the use of the pre-processor filter called Optical enhancement

Optical magnification without Optical enhancement

Ecuadorian Institute of Digestive Diseases, Omnihospital

Minimal Injuries From Esophagus Detected by Optical Enhancement System™ Associated to Optical Magnification HD Scopes

Mucosal and Minimal Injuries Detected Through Digital Chromoendoscopy Using Optical Enhancement System™ Associated to High Definition Plus Optical Magnification in Non Erosive Gastroesophageal Reflux Disease

Instituto Ecuatoriano de Enfermedades Digestivas

Liquid nitrogen spray cryotherapy with the truFreeze device

Liquid nitrogen spray cryotherapy with the truFreeze device
Liquid nitrogen spray cryotherapy with the truFreeze device: Low-pressure liquid nitrogen is sprayed through an upper endoscope on the diseased esophageal tissue to freeze and destroy it. The upper endoscope enables direct visualization of mucosal freeze during spray of the liquid nitrogen onto the mucosa and avoids the need for direct contact with the tissues. The target area is frozen and thawed for several consecutive cycles. The treated tissue becomes necrotic and sloughs, with new, healthy tissue regenerating in its place.

Cryotherapy

Sex: Female, Male

Race and Ethnicity Not Collected

The primary endpoint is to determine the response rate to spray cryotherapy.
It is hypothesized that one of the two following outcomes will occur:
Complete response to therapy: complete tumor eradication confirmed through histologic examination of biopsy specimens from the targeted esophageal tissue site;
Stable disease: tumor remission is not attained, but disease progression is halted.

Treated with liquid nitrogen spray cryotherapy

Treatment

Response Rate to Therapy

Disease-free Survival at 12 Months After Treatment

Cancer Recurrence Rate at 12 Months After Treatment

Estimate Overall Survival

Estimate Progression-free Survival in Those Who do Not Achieve Complete Pathologic Response

Number of Treatment Sessions Needed for Complete Response in Subjects in Whom the Primary Endpoint is Attained;

Number of participants with adverse events; Number of adverse events within the study

Safety of Spray Cryotherapy in This Setting;

Overall Study

Dr. Bruce Greenwald

Esophageal Cancer

Low-pressure liquid nitrogen is sprayed through an upper endoscope on the diseased esophageal tissue to freeze and destroy it. The upper endoscope enables direct visualization of mucosal freeze during spray of the liquid nitrogen onto the mucosa and avoids the need for direct contact with the tissues. The target area is frozen and thawed for several consecutive cycles. The treated tissue becomes necrotic and sloughs, with new, healthy tissue regenerating in its place.

University of Maryland Medical Center

Spray Cryotherapy for Esophageal Cancer (ICE-CANCER)

A Phase II, Multi-Center Study of Interventional Spray Cryotherapy for Early-Stage Esophageal Cancer (ICE-CANCER)

Bruce Greenwald

Professor of Medicine

University of Maryland, Baltimore

Head and Neck Neoplasms

Northwestern University

Oropharyngeal Function After Radiotherapy With IMRT

The patient has a normal diet when he or she includes all consistencies (thin liquid, thick liquid, pudding, pureed, soft mechanical, hard mechanical)

esophageal stenosis/buồn nôn

Minimal Injuries From Esophagus Detected by Optical Enhancement System™ Associated to Optical Magnification HD Scopes

Spray Cryotherapy for Esophageal Cancer (ICE-CANCER)

Oropharyngeal Function After Radiotherapy With IMRT

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