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The effect of oral administration of spray-dried microcapsules of feruloyl esterase (FE) producing Lactobacillus fermentum CRL1446 (Lf) and Lactobacillus johnsonii CRL1231 (Lj) on high fat diet-induced obese mice was investigated to evaluate whether these strains could be used as a biotherapeutic
Increased lipogenesis, together with hyperlipidemia and increased fat deposition, contribute to obesity and associated metabolic disorders including nonalcoholic fatty liver disease. Here we show that carboxylesterase 1/esterase-x (Ces1/Es-x) plays a regulatory role in hepatic fat metabolism in the
The present experiments were carried out to elucidate the effect of mazindol feeding on obese mice made by gold-thioglucose injection. Mazindol was added to the diet at the level of 0.5, 2, 10 mg/kg body weight. It was found that oral administration of mazindol reduced the body weight gain and
Subcutaneous adipose tissue development was studied in Yorkshire (lean) and Ossabaw (obese) pigs. Three pigs of each breed were slaughtered at 1 to 2 (group 1), 14 to 20 (group 2), 56 to 70 (group 3) and 180 (group 4) days of age. Formalin and(or) Bouin's fixed paraffin sections were analyzed by
Several techniques for the identification of the young obese Zucker rat were developed and tested. A procedure utilizing biopsies of hypodermal adipocytes was successful in identifying the obese phenotype in large litters of 7-d and older rats. This technique involves sizing and counting fat cells
The cellularity and histochemistry of the semitendinosus muscle was studied in lean and obese pigs at 14 days of age. Muscles from lean animals had lower (P less than .05) muscle weights and minimum fiber diameters and had reduced (P less than .05) percentages of dry matter and protein when
To study the effects of a prolonged (80 day), severe (64% body mass loss) energy restriction and subsequent refeeding on skeletal muscle tissue, specifically the plantaris muscle, 21 genetically obese Zucker rats were selected for this study. Six rats were initially killed and served as baseline
BACKGROUND
Despite the worldwide obesity epidemic, there have been very few studies investigating the influence of body weight on treatment dosing and outcomes in patients with hereditary angioedema (HAE).
OBJECTIVE
The purpose of this analysis was to determine whether the standard weight-based
BACKGROUND
Obesity became a major public health problem as a result of its increasing prevalence worldwide. Paraoxonase-1 (PON1) is an esterase able to protect membranes and lipoproteins from oxidative modifications. At the PON1 gene, several polymorphisms in the promoter and coding regions have
Spontaneous autoimmune thyroiditis in obese strain (OS) chickens provides an excellent animal model for the study of Hashimoto's autoimmune thyroiditis in humans. The data presented in this paper indicate that nonspecific esterases (NSE) may play a role in or serve as a marker for the target organ
The differentiation of perirenal adipose tissue was ascertained in fetuses from Ossabaw (wild and obese) and cross-bred lean dams at 70, 90 and 110 days gestation and from domestic lean and obese dams (USDA) at 110 days gestation. Condensation of presumptive adipocyte clusters was more apparent in
The cellular and enzyme-histochemical differentiation of subcutaneous adipose tissue was studied in lean and obese pig fetuses at several ages. Positive reactions for a variety of cytosolic and organellar enzyme markers indicate metabolic competence of fetal adipocytes despite their small size (12
Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex