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Introduction Knee osteoarthritis is a common disease of joint degeneration. Chronic inflammation is the major cause of this disease. One-third of the people over 65 years of age have Knee OA and the prevalence in women is more than in men. One-third of the people over 65 years of age have Knee OA
The study was approved by the Research Ethics Committee of the Clinical Hospital (Hospital das Clinicas), University of São Paulo (Universidade de São Paulo - USP) under number 0253/11.
This patient population is estimated to a total of 40 knees, with the patients meeting the following inclusion
Introduction:
The medical management of knee osteoarthritis (OA performing intra-articular treatment with hyaluronic acid (HA) has recently become more widely accepted. The effectiveness of HA regarding the improvement of pain and function - also compared to placebo - has been shown by in vitro and
Reduced knee function is a significant cause of physical limitations and disability. As cartilage deteriorates due to aging, wear-and-tear, injury, or disease, joint space narrowing and pain can develop. The lost of articular cartilage arises from an imbalance between cartilage synthesis and