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RELATED APPLICATIONS
This application is a national stage filing under 35 U.S.C. .sctn.371 of international application PCT/AT2008/000428, filed Dec. 3, 2008, designating the United States of America, and which was published under PCT Article 21(2) in English.
The present invention relates to a
FIELD OF THE INVENTION
The present invention relates to the field of benign prostatic hypertrophy, and in particular to the use of modified pore-forming proteins for the treatment of benign prostatic hyperplasia (BPH).
BACKGROUND OF THE INVENTION
Many cytolytic proteins have been described (Lesieur
INCORPORATION OF SEQUENCE LISTING
The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled, "PTX0006-509C1_20150615_SequenceListing", which is 78,861 bytes in size. The information in the electronic format of the
BACKGROUND OF THE INVENTION
Mucus glycoproteins are the major constituents of the mucosal layer found in the upper and lower airways of mammalian lungs [Rose. M. C. (1992), Am. J. Physiol. 263:L413-LA29]. Mucus confers the viscoelastic properties upon airway secretions and thus provides for the