Aprepitant L-proline solvate compositions and aprepitant L-proline solvate cocrystals are disclosed as well as pharmaceutical compositions containing them. The compositions and cocrystals of the invention are: 1:1:1 aprepitant L-proline methanol composition; a 1:1:1 aprepitant L-proline methanol cocrystal; a 1:1:1:1 aprepitant L-proline ethanol composition; a 1:1:1 aprepitant L-proline ethanol cocrystal; 1 1:1:1 aprepitant L-proline n-propanol composition; and a 1:1:1 aprepitant L-proline n-propanol cocrystal: The aprepitant L-proline solvate compositions or cocrystals may be used in the same way as aprepitant to treat or prevent disorders relating to emesis, a neuropsychiatric disease, an inflammatory disease, pain, cancer, a skin disease, itch a respiratory disease, or an addiction.

NUFORMIX LIMITED

Aprepitant L-proline solvates--compositions and cocrystals

A 1:1:1 aprepitant L-proline H.sub.2O composition and a 1:1:1 aprepitant L-proline H.sub.2O cocrystal are disclosed as well as pharmaceutical compositions containing a 1:1:1 aprepitant L-proline H.sub.2O composition or cocrystal and a pharmaceutically acceptable carrier. The 1:1:1 aprepitant L-proline H.sub.2O composition or cocrystal may be used in the same way as aprepitant to treat or prevent disorders relating to emesis, a neuropsychiatric disease, an inflammatory disease, pairs, cancer, a skin disease, itch, a respiratory disease, or an addiction.

Holland; Joanne

Frampton; Christopher

Chorlton; Alan

Gooding; Daniel

Nuformix Limited

Aprepitant L-proline composition and cocrystal

The invention relates to compounds of Formulae I(a) to XI ##STR00001## ##STR00002## ##STR00003## ##STR00004## and pharmaceutically acceptable salts and solvates thereof (Proline Analog Compounds), that are useful, e.g., as ligands for cannabinoid receptors, as compositions comprising a Proline Analog Compound and a pharmaceutically acceptable carrier, in methods of making such Proline Analog Compounds, and in methods for treating or preventing a Condition, such as pain, nausea, vomiting and an eating disorder, comprising administering an effective amount of a Proline Analog Compound to an animal in need thereof.

Purdue Pharma L.P.

Proline analogs as ligands for cannabinoid receptors

proline

vomiting

proline/vomiting

Aprepitant L-proline solvates--compositions and cocrystals

Aprepitant L-proline composition and cocrystal

Proline analogs as ligands for cannabinoid receptors

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