Shoulder Osteoarthritis

Cuff Tear Arthropathy

Massive Rotator Cuff Tear

Pre-Operative Interscalene block: 3-5mL of 0.5% bupivacaine plus 10mL Exparel (1-2 mg of midazolam and/or 50-100 mcg of fentanyl IV for sedation)

Interscalene regional block

Local infiltration injection intraoperatively prior to closing during the procedure. A standardized dose of 100 mL of infiltration will be utilized according to the following formula. The mixture will be injected into the deltoid and pectoralis major muscles and fasciae, and subcutaneous tissues using an 18-guage needle.
Total dose 100mL
Ropivacaine 0.5% 40mL Epinephrine 1mg/mL 0.1mL Ketorolac 30mg/mL 1mL Morphine 10mg/mL 0.5mL Normal saline 0.9% 58.4mL

Local infiltration analgesia

University of Missouri

Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty

Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty: A Randomized Controlled Trial

Following surgery, the patient's pain level will be recorded in a visual analog scale (VAS) at 4 hours, 8 hours, 12 hours, 24 hours, 2 days and daily until 7 days, and then at 14 days.

The patient's daily opiate consumption during the first 7 days following surgery and the toal accumulated amount of opiate consumption by 2 weeks postop will also be recorded, quantified and converted to morphine equivalents units (MEU) for standardization

Postoperative complications (medical, nerve injury, dislocation, hematoma, and wound complications)

Intraoperative complications (fracture, vascular injury, and anesthesia-related),

Individual participant data (IPD) will be shared with other members of the research team.

H. Mike Kim

ASSOCIATE PROFESSOR OF CLINICAL ORTHOPAEDIC SURGERY

University of Missouri-Columbia

Patients will be randomized prior to their scheduled surgery date by our research team using a randomization protocol developed by our department biostatistics team. The surgeons and anesthesiologists will be blinded about the group assignment until the day before surgery. The group assignment will be sealed in an envelope and delivered to the surgeon.

Restless Legs Syndrome

Topiramate

Neurocare

Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndrome

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Determine the Effacy and Safety of Topiramate in Subjects With Restless Legs Syndrome (RLS)

radiculopathy/buồn nôn

Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty

Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndrome

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