Patient who diagnostic of Breast cancer, Colorectal cancer, cancer of Ovary, and cancer of Endometrial are can recruit.

Breast Cancer

Colorectal Cancer

Cancer of Ovary

Cancer of Endometrium

Diagnosis and acceptance of breast cancer, colon rectal cancer, ovarian cancer, and endometrial cancer by the clinical Western medicine team.

Cases for patients diagnosed with breast cancer, colonrectal cancer, ovarian cancer and endometrial cancer

China Medical University Hospital

Immunoassay and Regulation of Traditional Chinese Medicine on Cancer Patients

The cytokines expression of immune cells in the blood by traditional Chinese medicine treatment in breast cancer, colon-rectal cancer, ovarian cancer, and endometrial cancer will be investigated.

Patients who undergone operation and TACE were administered 1.35 g cidan capsules (Weida Pharmaceutical Co., Ltd., Beijing, China) three times a day for 3 months.

Patients were only accepted operation and TACE.

Hepatocellular Carcinoma

Cidan capsule

Eastern Hepatobiliary Surgery Hospital

A Prospective Control Study of Cidan Capsule Combined With TACE in Hepatocellular Carcinoma

A Prospective Randomized Control Study of Cidan Capsule Combined With Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma

Zheng Donghai

Vice-President of Beijing Weida Cancer Hospital of Chinese Traditional Medical Sciences

Patients in single agent dose escalation arm will receive a single IV dose of 2B3-101 on day 1 of each cycle. In order to minimize the risk of infusion reactions 5% of the total dose of 2B3-101 (in mg) should be infused slowly over the first 30 minutes. If tolerated, the infusion may then be completed over the next hour for a total infusion time of 90 minutes.

HER2+ breast cancer patients with brain metastases will receive a single IV dose of 2B3-101 on day 1 of each cycle. In order to minimize the risk of infusion reactions 5% of the total dose of 2B3-101 (in mg) should be infused slowly over the first 30 minutes. As long as 2B3-101 is well tolerated, the remaining 95% of the infusion could thereafter be administered over the next 60 min, resulting in a total infusion time of 90 minutes. The infusion of trastuzumab will then follow 30 minutes after the completion of the 2B3-101 infusion.

Patients in the breast, Small Cell Lung Cancer and melanoma dose expansion arms will receive a single IV dose of 2B3-101 on day 1 of each cycle. In order to minimize the risk of infusion reactions 5% of the total dose of 2B3-101 (in mg) should be infused slowly over the first 30 minutes. If tolerated, the infusion may then be completed over the next hour for a total infusion time of 90 minutes.

Patients in the single agent glioma dose expansion arm will receive a single IV dose of 2B3-101 on day 1 of each cycle. In order to minimize the risk of infusion reactions 5% of the total dose of 2B3-101 (in mg) should be infused slowly over the first 30 minutes. If tolerated, the infusion may then be completed over the next hour for a total infusion time of 90 minutes.

Brain Metastases

Lung Cancer

Melanoma

Malignant Glioma

2B3-101

Trastuzumab

2B3-101 60 mg/m2 every 4 weeks

2B3-101 50 mg/m2 every 3 weeks

UNC Lineberger Comprehensive Cancer Center

Universitair Ziekenhuis Antwerpen

Jules Bordet Institute

Institut Curie

Institut Gustave Roussy

Antoni van Leeuwenhoek Ziekenhuis

Vrije Universiteit medisch centrum (Vumc)

Leids Universitair Medisch Centrum (LUMC)

Maastricht Universitair Medisch Centrum

Erasmus MC

An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.

BBB-Therapeutics B.V.

salvia

chống ung thư

anticancer

salvia/chống ung thư

Immunoassay and Regulation of Traditional Chinese Medicine on Cancer Patients

A Prospective Control Study of Cidan Capsule Combined With TACE in Hepatocellular Carcinoma

An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.

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