A pyrazolidine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CH.sub.2 --, --CO--, --CS--, --CH.sub.2 CO--, or --CH.dbd.CH--CO--; B represents a group expressed by --O-- or --NH--; n is an integer of 1 or 2; R represents an alkenyl group; and R.sub.1 and R.sub.2 represent a lower alkyl or benzyl group.The pyrazolidine derivative above mentioned, as a radical scavenger, has antioxidant effect and lipid peroxidation inhibitory activity so as to be available for inhibiting brain infarction or brain edema.

Shiseido Co., Ltd.

Pyrazolidine derivative radical scavenger brain-infarction depressant and brain-edema depressant

A phenylenediamine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CO--, --CH.sub.2 CO--, --CS--, or --SO.sub.2 --; Y represents a carbon atom or nitrogen atom; R.sub.1 represents a lower alkyl group; R.sub.2 represents a hydrogen, lower alkyl, alkenyl, benzyl, or benzoyl group; and each of R.sub.3 and R.sub.4 represents an alkyl group having 1-10 carbon atoms. The phenylenediamine derivative above mentioned, as a radical scavenger, has antioxidant effect and lipid peroxidation inhibitory activity so as to be available for inhibiting brain infarction or brain edema.

Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant

The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.

University of North Carolina at Charlotte

Composition and method for the restoration and preservation of transplant organs procured from DCD donors

Lee; Charles Y.

Clemens; Mark G.

Zhang; Jian X.

Jain; Shailendra

A method for noninvasive treatment of diabetic retinopathy helps prevent and reverses diabetic retinopathy and other vascular retinopathies, such as diabetic macular edema for a patient. The method comprises administering at least 80 percent pure oxygen to a patient in an oxygen chamber or nasal cannula. The oxygen chamber includes light emitting diodes that emit a light having a wavelength between 630-700 nm wavelengths on the patient. The method also includes administering an anti-inflammatory agent; an anti-oxidant; at least one of the following: an amino acid, arginine, and citrulline; and an omega-3 fatty acids to the patient. In extreme cases of diabetic retinopathy, a cold laser therapy is also administered to the patient with a wavelength between 570 nanometers and 1000 nanometers. The combination of all the aforementioned treatment modalities and compositions that work to synergistically to achieve unexpected clinical results for prevention and reversal of diabetic retinopathy.

antioxidant/edema

Pyrazolidine derivative radical scavenger brain-infarction depressant and brain-edema depressant

Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant

Composition and method for the restoration and preservation of transplant organs procured from DCD donors

Composition and method for the restoration and preservation of transplant organs procured from DCD donors

Method of noninvasive treatment of diabetic retinopathy

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