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FIELD OF THE INVENTION
The present invention relates to compositions comprising sulfated polysaccharides and uses thereof.
BACKGROUND OF THE INVENTION
According to the world health organization (WHO), reproductive and sexual ill-health accounts for 20% of the global sickness in women and therefore
This is a National Phase Application in the United States of International Patent Application No. PCT/GB2008/002067, filed Jun. 17, 2008, which claims priority to Great Britain Patent Application No. 0711948.0, filed Jun. 20, 2007.
FIELD OF THE INVENTION
This invention pertains to neurosteroid
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a 371 of PCT/EP2013/066560, filed Aug. 7, 2013, which claims the benefit of European Patent Application No. RM2012A000404, filed Aug. 9, 2012.
FIELD OF THE INVENTION
The present invention concerns the medical field, and in particular
FIELD OF THE INVENTION
The present invention provides methods and compositions for the use of IL-22 to promote thymic growth following thymic insult. In particularly preferred embodiments, the present invention provides methods of using therapeutic IL-22 compositions for treating patients with
FIELD OF THE INVENTION
The present invention provides methods and compositions for the use of IL-22 to promote thymic growth following thymic insult. In particularly preferred embodiments, the present invention provides methods of using therapeutic IL-22 compositions for treating patients with
BACKGROUND OF THE INVENTION
Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii) neuronal fate determination of NSC; (iii) survival and maturation of new neurons; and (iv) functional
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of International Application No. PCT/EP2014/066123 having an international filing date of Jul. 28, 2014 and which claims benefit under 35 U.S.C. .sctn.119 to European Patent Application No. 13178373.0 filed Jul. 29, 2013. The
BACKGROUND OF THE INVENTION
Now it has been shown that the present compounds stimulate neurogenesis from neural stem cells (NSCs). Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii)
The present invention relates to compounds of general formula
##STR00002## wherein Ar is phenyl or pyridinyl; X.sup.1 is N or CH, X.sup.2 is N or CH, with the proviso that only one of X.sup.1 or X.sup.2 is N and the other is CH; R.sup.1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl
The present invention relates to the use of compounds of general formula
##STR00002## wherein R.sup.1 is phenyl or pyridinyl, which are optionally substituted by halogen, cyano or lower alkyl substituted by halogen, or is dihydro-pyran-4-yl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is
TECHNICAL FIELD
This presently disclosed embodiments relate generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of
TECHNICAL FIELD
This presently disclosed embodiments relate generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of
TECHNICAL FIELD
This invention relates generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of newly formed neurons
TECHNICAL FIELD
This presently disclosed embodiments relate generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of
TECHNICAL FIELD
This presently disclosed embodiments relate generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of