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Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis

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Aim and Objective - AIM- To compare the efficacy and safety of tranexamic acid in reducing 5-day treatment failure (i.e., failure to control bleed) in patients with cirrhosis presenting with Upper GI bleed Primary Objective: Proportion of patients developing five-day treatment failure (i.e., failure

Early Use of Long-acting Tacrolimus in Lung Transplant Recipients

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Lung transplantation is a life-saving therapy for patients with end-stage lung disease refractory to medical treatment, providing an improvement in both survival and quality of life.[1,2] Despite the benefits, patients are at risk for myriad side effects including infection, malignancy, neurologic
The purpose of this study is to conduct a comparison in patients' cardiac function, ECG, and pacemakers' threshold value, time limit and so on among dual chamber pacemaker and HBP. The clinic trial is about to conduct pacemaker implantation in 84 participants, which distribute into dual chamber
The purpose of this study is to conduct a comparison in patients' cardiac function, ECG, and pacemakers' threshold value, time limit and so on among dual chamber pacemaker, and HBP. The clinic trial is about to conduct pacemaker implantation in 84 participants, which distribute into dual chamber

S100β and Neuron Specific Enolase Levels in Liver Transplantation

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Neurologic disorders that affect the liver transplantation candidates when they are on the waitlist not only significantly affect preoperative morbidity and even mortality but also present important predictive factors for post-op neurologic manifestations. Attentive neurological evaluation before
Subarachnoid hemorrhage (SAH) consists of blood extravasation into the space between arachnoid and pia mater. Bleeding is a consequence of cerebral aneurysm rupture in most cases. It particularly affects females with an average age of 55 years. Despite incidence being only 9 cases out of 1000 people
Experimental Design: This Phase 2 study will be done prospectively and will be conducted in two stages. The initial stage will be the general study and the second stage will be the sub-study. We plan to screen up to 1,000 subjects. Our enrollment goal is 250 subjects total (with 50 subjects enrolled

Treatment for Alcohol Dependence With Gabapentin

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The study will be conducted on patients with alcohol dependence admitted or coming to the out patient department. The enrolled subjects will be divided into two groups randomly using computer generated randomization system. Informed consent shall be taken from the patient/nearest relative of the

Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders

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BACKGROUND, SIGNIFICANCE, AND RATIONALE Failure to thrive or inadequate weight gain is a frequent complaint amongst patients seen by general pediatricians and pediatric gastroenterologists. The reasons behind this diagnosis vary widely including, but not limited to feeding disorders of diverse
With an occurrence of up to 30%, hyponatremia, defined as a serum sodium concentration of less than 135 mmol/L, is the most commonly encountered electrolyte disorder in hospitalized patients today. The highest incidence of hyponatremia is found in the elderly. Retrospective analyses clearly show an
1. HYPOTHESIS AND OBJECTIVES PEG-IFN as an immunomodulatory agent could potentiate the antiviral efficacy of patients on long term nucleos(t)ide analogue therapy and improve early indicators of efficacy, HBeAg loss and reduction in qHBsAg. This study will also test whether add-on compared to switch
BROCHURE: Name of Study: Neuropsychological and Neuroanatomical Studies in Young Children Study Directors: Tandy Aye, MD; Bruce Buckingham, MD; Darrell Wilson, MD About the Study: This study is being conducted to see if Type 1 diabetes mellitus has any affect on learning, behavior and development in

Praziquantel-Pharmacokinetic Study

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Schistosomiasis infects over 200 million individuals and remains a significant cause of morbidity and mortality in developing countries, despite the availability of effective pharmacologic therapy with praziquantel (PZQ). Researchers propose to conduct a phase I study of the pharmacokinetics (PK)

Target Temperature Management After Cardiac Arrest

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Detailed statistical analysis plan for the Target Temperature Management after Out-of-hospital Cardiac Arrest trial 1. Introduction The Target temperature management after out-of-hospital cardiac arrest, a randomised, parallel-group, assessor-blinded clinical trial (the TTM-trial) is the largest
Niemann-Pick Disease, type C (NPC) is an autosomal recessive lysosomal storage disease with progressive neurodegeneration. It is characterized by intracellular accumulation of cholesterol and glycosphingolipids. The age of onset is variable with cases manifesting from infancy to adulthood.
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