Life Sciences 1982-Mar
Brain water and electrolytes in response to respiratory acidosis and brain edema in the mutant mouse, jimpy.
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Compared to littermate controls, unstressed Jimpy mice have higher brain water, sodium, potassium and chloride contents and lower carbonic anhydrase activity. When stressed by CO2 to produce a respiratory acidosis or by injection of distilled water to produce brain edema, the Jimpy mouse brain has water and ionic responses essentially like those in controls.