Arzneimittel-Forschung 2008
New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
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Melanin-concentrating hormone (MCH) is a recently discovered central nervous system (CNS) target for treating obesity. Two novel series of amide derivatives were synthesized and evaluated biologically as MCH-R1 (melanin-concentrating hormone receptor 1) antagonists. The results showed that diphenyl substituents on the amide lead to better activity than biphenyl substituents.
