Anti-inflammatory Dendranacetylene A, a new polyacetylene glucoside from the flower of Chrysanthemum morifolium Ramat

A new polyacetylene glucoside, Dendranacetylene A (1), and a known compound 8E-decaene-4,6-diyn-1-O-β-d-glucopyranosyl-(1"→2")-β-d-glucopyranoside (2) were isolated from the flowers of Dendranthema morifolium (Ramat.) kitam. The chemical structures of these compounds were elucidated by NMR and HR-ESI-MS analysis, and comparing these results with data reported in literatures. Additionally, the anti-inflammatory effects of compounds 1 and 2 were evaluated on RAW264.7 murine macrophage cells induced by lipopolysaccharide (LPS). The two compounds significantly inhibited the NO production in LPS-induced RAW 264.7 murine macrophage cells and exhibited anti-inflammatory effects.

Keywords: Chrysanthemum morifolium Ramat; RAW264.7 murine macrophage cells; anti-inflammatory activity; polyacetylene glucoside; structural elucidation.