patients in this arm should meet the inclusion criteria and the definition of refractory UME

Uveitis

Macular Edema

Vascular Endothelial Growth Factor

Effect of Drugs

patients will receive intravitreal injection of Conbercept, and at the same time, aqueous humor sample will be obtained from the anterior chamber to measure the concentrations of cytokines.

intravitreal injection of Conbercept

Peking Union Medical College Hospital (PUMCH)

Effects of Conbercept in Refractory Uveitic Macular Edema and VEGF

Effectiveness of Conbercept in Treating Refractory Uveitic Macular Edema and the Changes of VEGF Levels in the Aqueous Humor

changes from baseline BCVA at 1, 2, 3, 4, 5, 6 months after injection (at each follow-up visit)

changes from baseline CRT at 1, 2, 3, 4, 5, 6 months after injection (at each follow-up visit)

inflammatory cytokines include VEGF-A, VEGF-B, interleukin (IL)-2, interleukin-6, interleukin-8, interleukin-10, interleukin-12, tumor necrosis factor (TNF) α, monocyte chemotactic protein-1 and macrophage inflammatory protein-1

changes from baseline flare and cells in the anterior chamber at 1, 2, 3, 4, 5, 6 months after injection

changes from baseline intraocular pressure at 1, 2, 3, 4, 5, 6 months after injection

whether cataract is developed or exacerbated

alpha prostaglandin f 2/ödəm

Effects of Conbercept in Refractory Uveitic Macular Edema and VEGF

Ibuprofen in Sepsis Study

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