Patients in this arm will receive vaginal misoprostol (50 mcg), the night before the procedure (concurrent office hsyteroscopy and endometrial biopsy).

Participants in this group will receive placebo (fatty acid), which looks similar to misoprostol and has to be inserted vaginally the night before the procedure.

Office Hysteroscopy and Endometrial Biopsy

Participants in the study arm will receive vaginal misoprostol (50 mcg) to be inserted the night before the procedure. Whereas the control group will get a placebo.

Misoprostol 50 mcg pesssary

The control group will receive placebo pessaries to be inserted vaginally the night before the procedure.

Placebos

University of South Florida, Department of Obstetrics and Gynecology

Misoprostol in Office Hysteroscopy and Endometrial Biopsy

Efficacy of Vaginal Misoprostol For Pain Relief During Office Hysteroscopy and Endometrial Biopsy; A Double Blind Randomized Controlled Trial

The current study aims to evaluate if vaginal misoprostol (50 mcg) administered prior to Office hysteroscopy and endometrial biopsy when performed successively in the same office visit decreases overall pain perception during the procedure among subgroup of women who are anticipated to have difficult entry into the cervical canal

We intend to investigate whether vaginal misoprostol use reduces the need for dilatation and eventually helps in successfully completing the procedures.

University of South Florida

A Double Blind Randomized Controlled Trial

The participants and the care providers (performing the procedure) will not know about the randomization. The research coordinator will perform the randomization and the medicine dispensed by the pharmacy. The study drug and placebo are similar looking, hence the participants and providers would not be able to identify them.

according to american academy of periodontology classification of periodontal diagnosis.

gingival crevicular fluid, serum, aminiotic fluid

Periodontal Disease

Adverse Pregnancy Outcome

Correlation Between Inflammatory Markers in Gingival Crevicular Fluid, Serum and Amniotic Fluids in Periodontal Pregnant Women

Using ELISA we will quantify the levels of inflammatory markers such as IL-6, TNFα and IL-1β.

We will also test the levels of endotoxin and perio-pathogens DNA in the serum and amniotic fluid using real time PCR and ELISA. Measures are a composite outcome measure consisting of multiple measures (results to be reported as a single value for each Arm/Group).

Polak David

senior physician

Hadassah Medical Organization

Patients receiving chemotherapy (anthracycline-based) will be randomized to esomeprazole for Cycle 1 Days 1-5 and Cycle 2 Days 1-5

Subjects will be given placebo Cycle 1 Days 1-5 and Cycle 2 Days 1-5.

Subjects will be given esomeprazole 40mg daily by mouth for Cycle 1 Days 1-5 and Cycle 2 Days 1-5.

Esomeprazole

Subjects will be given placebo(surgar pill) 40mg daily by mouth for Cycle 1 Days 1-5 and Cycle 2 Days 1-5.

Sugar Pill

Total

Age, Customized

Sex: Female, Male

Proportion of patients who exhibit no more than one emetic episode and who do not require rescue medication for nausea from 2-7 days following chemotherapy. Thus, we will look at esomeprazole when used to decrease the incidence,severity and duration of nausea/vomiting/retching in breast cancer patients who are receiving anthracycline-based chemotherapy.

The first dose of esomeprazole 40 mg will be administrated prior to the initiation of chemotherapy along with the standard antiemetics for each cycle. On day 2 to 5 following chemotherapy, the patient will take one capsule each morning.

The frist dose of sugar pill 40 mg will be administrated prior to the initiation of chemotherapy along with the standard antiemetics for each cycle. On day 2 to 5 following chemotherapy, the patient will take one capsule each morning.

Number of Times a Subject Felt Sick to Her Stomach and Number of Times a Subject Required Rescue Medication

Overall Study

Mothaffar Rimawi

The frist dose of esomeprazole 40 mg will be administrated prior to the initiation of chemotherapy along with the standard antiemetics for each cycle. On day 2 to 5 following chemotherapy, the patient will take one capsule each morning.

Nausea

esomeprazole

Placebo 1 pill daily Cycle 1 Days 1-5 and Cycle 2 Days 1-5

alpha prostaglandin f 2/kariyes

Misoprostol in Office Hysteroscopy and Endometrial Biopsy

Correlation Between Inflammatory Markers in Gingival Crevicular Fluid, Serum and Amniotic Fluids in Periodontal Pregnant Women

Nexium Study To Suppress Nausea During Chemotherapy

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