The present invention provides the use of a tocopherol or a derivative thereof as a solvent and/or emulsifier for substantially insoluble and sparingly soluble biologically active agents, especially in the manufacture of pharmaceutical compositions. Such compositions are particularly suitable for transmucosal, and especially intranasal or rectal administration, or administration via the oral cavity.

A/S Dumex

(Copenhagen, DK

Tocopherol compositions for delivery of biologically active agents

A clear aqueous formulation for topical application in the oral cavity of humans to treat leukoplakia contains water, .beta.-carotene, a water miscible polyol, an unsaturated fatty acid ester, and a surfactant, preferably polyethoxylated castor oil. The formulation preferably also contains a pharmaceutically acceptable anti-oxidant, preferably d-alpha-tocopherol (vitamin E), and is in the form of an oral rinse or as a gel well suited for spreading on gums or other parts of the oral cavity. The formulation is applied in a gel form on a substantially regular daily basis to areas in the oral cavity where leukoplakia lesions are present. Persistent application of the gel results in substantial diminution or total elimination of the leukoplakia lesions.

Micelle Products, Inc.

Clear micellized formulations of .beta.-carotene and method of treating leukoplakia

A clear aqueous formulation for topical application in the oral cavity of humans to treat leukoplakia contains water, .beta.-carotene, a water miscible polyol, an unsaturated fatty acid ester, and a surfactant, preferably polyethoxylated castor oil or POE(20) sorbitan monooleate. The formulation preferably also contains a pharmaceutically acceptable anti-oxidant, preferably d-alpha-tocopherol (vitamin E), and is in the form of an oral rinse or as a gel well suited for spreading on gums or other parts of the oral cavity. The formulation is applied in a gel form on a substantially regular daily basis to areas in the oral cavity where leukoplakia lesions are present. Persistent application of the gel results in substantial diminution or total elimination of the leukoplakia lesions.

alpha tocopherol/kariyes

Tocopherol compositions for delivery of biologically active agents

Clear micellized formulations of .beta.-carotene and method of treating leukoplakia

Clear micellized formulations of .beta.-carotene and method of treating leukoplakia

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