Subjects in the siltuximab group will receive an 11 mg/kg infusion at baseline, and weeks 3 and 6, as per the recommended dosing for multicentric Castleman's disease

Subjects in the placebo group will receive an infusion of normal saline (with the same packaging and volume as the siltuximab group) at baseline, and weeks 3 and 6.

Schizophrenia

Psychotic Disorders

Siltuximab

normal saline

Augusta University

Siltuximab in Schizophrenia

A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia

The Brief Assessment of Cognition in Schizophrenia (BACS) is the metric used to characterize cognition in this study. The BACS consists of 6 subscales: Verbal Memory (range 0-75), Working Memory (range 0-28), Motor Speed (range 0-100), Verbal Fluency (measure is total number of words generated in two 60 second trials), Attention and Processing speed (range 0-110), and Executive Function (range 0-22). For each subscale, higher scores reflect better cognition. For each subscale, a Standard Deviation Score was calculated based on normative data (Keefe et al. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS). Schizophrenia Research 102 (2008) 108-115). The BACS composite score is calculated as the average Standard Deviation Score of the 6 subscale scores. The change in BACS composite score will be calculated as the BACS composite score at 9 weeks minus the BACS composite score at baseline.

The Positive and Negative Symptoms Scale (PANSS) is the metric used to characterize psychotic symptoms in this study. The PANSS consists of 30 items, each scored 1-7. The range for the PANSS total score is 30-210. There are 3 subscales - PANSS positive score (range 7-49), PANSS negative score (range 7-49), and PANSS general score (range 16-112). PANSS total score is the summation of these 3 subscales. Higher values for the total and subscale scores reflect more severe psychopathology. A positive change in PANSS total score reflects an increase in psychopathology. A negative change in PANSS total score reflects a decrease in psychopathology.

Brian Miller

Associate Professor

Stanley Medical Research Institute

Diarrhoea

Severe Malnutrition

Amylase resistant starch added ORS

ICDDR,B

Oral Rehydration SolutionContaining Amylase Resistant Starch in Severely Malnourished Children.

Oral Rehydration SolutionContaining Amylase Resistant Starch in Severely Malnourished Children With Watery Diarrhoea Due to Vibrio Cholerae

International Centre for Diarrhoeal Disease Research, Bangladesh

Nestlé Foundation

Testing Effect of Intervention

Children in the zinc group received 20 mg of elemental zinc as acetate per day in a twice-daily dose for two weeks.

Zinc Supplementation in Shigella Patients

Effect of Zinc Supplementation on the Immune and Inflammatory Responses of Children to Shigella Flexneri Infection, and Correlation With Clinical Severity of Illness and Growth Following recoveryEffect of Zinc Supplementation on the Immune and Inflammatory Responses of Children to Shigella Flexneri Infection, and Correlation With Clinical Severity of Illness and Growth Following Recovery

Karolinska Institutet

Acute Schizophrenia

niacinamide

pyridoxine

ascorbate

Beersheva Mental Health Center

Treatment of Acute Schizophrenia With Vitamin Therapy

The Treatment of Acute Schizophrenia With High Dose Niacinmide Plus Ascorbate Plus Pyridoxine Plus Centrum Forte vs. Centrum Forte Only as an Add-On to Risperidone and Dietary Counseling

nicotinamide/diarreya

Siltuximab in Schizophrenia

Oral Rehydration SolutionContaining Amylase Resistant Starch in Severely Malnourished Children.

Zinc Supplementation in Shigella Patients

Treatment of Acute Schizophrenia With Vitamin Therapy

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