Patients with primary biliary cirrhosis are treated 3 months with OCA (active drug) or placebo in a double-blind cross-over study design.

Primary Biliary Cirrhosis

Obeticholic acid

Placebos

Susanne Keiding

Effect of Obeticholic Acid on Transport of Bile Acids in PBC Examined by 11C-cholyl-sarcosine PET/CT

Effect of Obeticholic Acid (INT-747, Intercept) on the Hepatobiliary Transport of Bile Acids in Patients With PBC Examined by 11C-cholyl-sarcosine PET/CT

University of Aarhus

Double blind placebo-controlled crossover

Codes (OCA or placebo) will be opened after final examination of final patient

Celiac Block with triamcinolone and bupivicaine Intra Plexus Triamcinolone and Bupivicaine Injection

Patients will undergo EUS but no celiac block will be performed

Pancreatitis, Chronic

Pancreatitis

Endosonography of the pancreas performed following by analgesic injection

Celiac Block with triamcinolone and bupivicaine

No Celiac Block

Injection of Triamcinolone and Bupivicaine into celiac plexus for pain relief

Intra Plexus Triamcinolone and Bupivicaine Injection

Los Angeles County Hospital

Celiac Plexus Block for Chronic Pancreatitis RCT

Prospective Randomized Trial of EUS Guided Celiac Plexus Block for Chronic Pancreatitis

Primary outcomes will be the CHANGE pain score (as assessed by the visual-analogue-scale and M-ANNHEIM score assessed between time 0 and 24 weeks post procedure in those who undergo EUS without block (control) compared to those who undergo EUS with block

differences in number of hospital re-admissions for pancreatic pain assessed at 24 weeks between those who underwent the block and did not undergo the celiac block

CHANGE in pain medication requirement 24 weeks following celiac block in those who underwent EUS guided celiac block compared to those who did not

Post procedure complications include infection (defined as fever or increased WBC without an alternative cause), diarrhea (defined as 3 loose stools per day), or pancreatitis (defined as increased pain and lipase >3 X the upper limit of normal). Will be assessed 2 weeks after the procedure and compared between those who EUS with block compared to EUS without block

oxalis exilis/diarreya

Effect of Obeticholic Acid on Transport of Bile Acids in PBC Examined by 11C-cholyl-sarcosine PET/CT

Celiac Plexus Block for Chronic Pancreatitis RCT

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