Patients needing intubation and mechanical ventilation for COVID-19 related pneumonia without other primary causes of ICU admission

COVID-19

Mechanical Ventilation

Quality of Life

Radiologic Increased Density of Lung

Sedation

Complication of Treatment

Invasive mechanical ventilation for respiratory failure associated to COVID-19 pneumonia

Invasive mechanical ventilation

Ospedale Santa Maria Annunziata - Anestesia e Rianimazione

A.O. SS. Antonio, Biagio e Cesare Arrigo - Anestesia e Rianimazione

Anestesia e Rianimazione - Ospedale Civile di Baggiovara

Anestesia e Rianimazione - Ospedale di Bentivoglio

Azienda Unità Sanitaria Locale

Anestesia e Rianimazione - Ospedale Bellaria

Anestesia e Rianimazione - Policlinico Universitario S.Orsola - Malpighi

Anestesia e Terapia intensiva dei trapianti addominali e chirurgia epatobiliare - Policlinico Universitario S.Orsola - Malpighi

Anestesia e Terapia Intensiva Polivalente - Policlinico Universitario S.Orsola - Malpighi

Ospedale SS. Trinità - Anestesia e Rianimazione

Anestesia e Rianimazione - Ospedale M. Bufalini

Anestesia e Rianimazione - Ospedale degli Infermi

Anestesia e Rianimazione Universitaria - Arcispedale Sant'Anna Ferrara

Anestesia e Rianimazione - Ospedale Morgagni - Pierantoni

Anestesia e Rianimazione - Ospedale di Imola S.Maria della Scaletta

Ospedale Santo Stefano - Anestesia e Rianimazione

Anestesia e Rianimazione - Ospedale S. Maria delle Croci

Anestesia e Rianimazione - Arcispedale Santa Maria Nuova

Anestesia e Rianimazione - Ospedale di Riccione

Anestesia e Rianimazione - Ospedale Infermi

Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome

Ventilator free days (VFDs) will be calculated in a time frame of 28 days, the beginning of observation will coincide with the day of intubation and observation will end after successful disconnection from mechanical ventilation.
For intubated patients, post extubation non invasive ventilation (NIV) will not be accounted as a ventilation period, in case of interval reintubation within 28 days, VFDs will be counted from the last successful extubation.
For tracheostomized patients, ventilator free days will be counted after successful disconnection from mechanical ventilation and interval reconnections will be considered in the ventilation interval as for intubated patients.

15D instrument (http://www.15d-instrument.net/15d/) will be administered via telephonic interview
Areas assessed: MOBILITY, VISION, HEARING, BREATHING, SLEEPING, EATING, SPEECH, EXCRETION, USUAL ACTIVITIES, MENTAL FUNCTION, DISCOMFORT AND SYMPTOMS, DEPRESSION, DISTRESS, VITALITY, SEXUAL ACTIVITY

First available CT, last CT before ICU admission and intubation, last ICU follow-up CT. First available chest X ray, last chest X ray before ICU admission and intubation, last ICU- follow up chest X ray and 30 days follow-up CT (if available) will be evaluated, if available.
Structured description
CT scan
Date: yyyy/mm/dd Parenchymal alterations: ground glass, crazy paving, parenchymal consolidation Extension: monolateral, bilateral Number of lobes involved: (1-5) Percentage of parenchymal involvement: 0-100% Distribution: subpleural, random, diffuse
X-ray scan
Date: yyyy/mm/dd Main aspects: normal, focal lesions, monolateral multifocal lesions (right/left), diffuse multifocal lesions Lesion aspects: interstitial, interstitial/alveolar, alveolar, consolidations Pleural effusion presence and entity
Pulmonary involvement score:
0 = no involvement
=< 25%
= 25-50% 3= 50-75%
4 => 75% Total score (0-6): score of the right lung + score of the left lung

Azienda Usl di Bologna

Lorenzo Gamberini

Celiac Block with triamcinolone and bupivicaine Intra Plexus Triamcinolone and Bupivicaine Injection

Patients will undergo EUS but no celiac block will be performed

Pancreatitis, Chronic

Pancreatitis

Endosonography of the pancreas performed following by analgesic injection

Celiac Block with triamcinolone and bupivicaine

No Celiac Block

Injection of Triamcinolone and Bupivicaine into celiac plexus for pain relief

Intra Plexus Triamcinolone and Bupivicaine Injection

Los Angeles County Hospital

Celiac Plexus Block for Chronic Pancreatitis RCT

Prospective Randomized Trial of EUS Guided Celiac Plexus Block for Chronic Pancreatitis

Primary outcomes will be the CHANGE pain score (as assessed by the visual-analogue-scale and M-ANNHEIM score assessed between time 0 and 24 weeks post procedure in those who undergo EUS without block (control) compared to those who undergo EUS with block

differences in number of hospital re-admissions for pancreatic pain assessed at 24 weeks between those who underwent the block and did not undergo the celiac block

CHANGE in pain medication requirement 24 weeks following celiac block in those who underwent EUS guided celiac block compared to those who did not

Post procedure complications include infection (defined as fever or increased WBC without an alternative cause), diarrhea (defined as 3 loose stools per day), or pancreatitis (defined as increased pain and lipase >3 X the upper limit of normal). Will be assessed 2 weeks after the procedure and compared between those who EUS with block compared to EUS without block

pneumothorax/diarreya

Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome

Celiac Plexus Block for Chronic Pancreatitis RCT

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