50 mg of PYC for the first 4 weeks and then switch over to receive placebo for the following 4 weeks

100 mg of PYC for the first 4 weeks and then switch over to receive placebo for the following 4 weeks

Placebo for the first 4 weeks and then switch over to 50 mg PYC for the following 4 weeks

Placebo for the first 4 weeks and then switch over to 100mg PYC for the following 4 weeks

Climacteric; Menorrhagia, Menopausal

Menopause

50 mg PYC and then placebo

100 mg PYC and then placebo

Placebo and then 50 mg PYC

Placebo and then 100 mg PYC

Legacy Mt. Hood Medical Center

Legacy Good Samaritan Medical Center

Legacy Meridian Park Medical Center

The Use of Pycnogenol® to Alleviate Menopausal Symptoms Induced or Increased by Breast and Gynecological Cancer Treatments

The MRS will be used to evaluate the efficacy of PYC in decreasing menopausal symptoms as compared to placebo. The difference-from-baseline (DFB) score will be calculated by taking the composite MRS score at 10 weeks and 12 weeks compared to the MRS score at baseline to determine whether or not PYC reduces symptoms, if the effects last beyond actively taking PYC, and if so, how long. The purpose of multiple time point assessments is two-fold: first, some patients will be taking placebo and some will be taking active drug in the first month, and vice versa during the second month. Therefore, an assessment needs to be done at each timepoint, weeks 4 and 8. Second, we are interested in understanding how long the symptoms management may last without actively taking drug, which accounts for the 10 week and 12 week timepoints.

Reza Antoszewska

Legacy Health Foundation

Legacy Health System

Lymphedema

Pycnogenol

Placebo

University of Wisconsin

Pycnogenol for the Treatment of Lymphedema

Treatment of Arm Lymphedema in Breast Cancer Survivors: A Double-Blind, Randomized Study of Pycnogenol vs. Placebo

University of Wisconsin, Madison

National Center for Complementary and Integrative Health (NCCIH)

Breast

Cancer

University of Wisconsin Comprehensive Cancer Center and School of Pharmacy

Pycnogenol for the Treatment of Lymphedema of the Arm in Breast Cancer Survivors

pycnogenol

xərçəng xəstəliyi

neoplasms

pycnogenol/xərçəng xəstəliyi

The Use of Pycnogenol® to Alleviate Menopausal Symptoms Induced or Increased by Breast and Gynecological Cancer Treatments

Pycnogenol for the Treatment of Lymphedema

Pycnogenol for the Treatment of Lymphedema of the Arm in Breast Cancer Survivors

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