Experimental group: anlotinib(d1-14, d22-36), followed by 21 days period, 2 weeks medication, 1 week maintenance therapy.
. Group II: 10 mg po qd, Group III: 12 mg po qd;
Combined chemotherapy:
Cisplatin + etoposide Or PC: carboplatin AUC2, paclitaxel 45-50 mg 2 per week; Cisplatin + cultured beauty (non squamous cell carcinoma). Synchrotron radiation: radiotherapy combined with radiotherapy (3D-CRT or IMRT) (60-66Gy / day).
The curative effect was evaluated after 6 weeks of simultaneous radiotherapy and chemotherapy combined with alotinib, and then the efficacy of alotinib or chemotherapy was maintained until PD.

Patients With Non-small Cell Lung Cancer

Simultaneous chemoradiotherapy for An Luo

The second affiliated Hospital of Xi'an Jiaotong University

Study of Anlotinib Plus Chemoradiotherapy in Patients With Locally Advanced NSCLC

Phase I / II Clinical Study on the Safety and Preliminary Efficacy of Anlotinib Hydrochloride Combined With Platinum-containing Simultaneous Radiotherapy in the Treatment of Locally Advanced Non-small Cell Lung Cancer

complete response(CR)+partial response(PR) according to RECIST 1.1

overall survival is defined as the time from randomization to death from any cause

progression-free survival is defined as the time from enrollment to the date of first document disease progression or death from any cause

Second Affiliated Hospital of Xi'an Jiaotong University

Tang-Du Hospital

Xijing Hospital

First Affiliated Hospital Xi'an Jiaotong University

Shaanxi Provincial Cancer Hospital

Shaanxi Provincial People's Hospital

Experimental group: anlotinib (D1-14, d22-36, followed by 21 days cycle, taking medicine for 2 weeks, stopping for 1 week).
Group 1: 8mg po qd, Group 2: 10mg po qd, Group 3: 12mg po qd;
Combined chemotherapy:
Cisplatin + etoposide or PC: carboplatin AUC2, paclitaxel 45-50 mg 2 per week; Cisplatin + pemetrexed (non-squamous cell carcinoma). Simultaneous radiotherapy: 3D-CRT or IMRT external radiotherapy (60-66 Gy, 2.0 Gy / day).
The curative effect was evaluated after 6 weeks of simultaneous radiotherapy and chemotherapy combined with alotinib, and then the efficacy of alotinib or chemotherapy was maintained until PD.

Infection, Bacterial

Antibiotic Resistant Infection

Diagnostic Self Evaluation

Meningitis, Bacterial

Nosocomial Infection

Neurosurgery dept. University Hospital

Neurosurgery department, University Hospital

Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.

analyse of different body fluids to detect the focus of infections post neurosurgical fever

Fariba Nayeri

MD, PhD, associated professor

A humidified mixture of gas will be delivered by mask, nasal cannulae, and small room-sized tent. Inspiratory oxygen fraction (FiO2) will be gradually decreased to 11% over a period or five days to obtain a peripheral capillary O2 saturation (SpO2) between 80%-85% (corresponding to 40-55 mmHg of arterial partial oxygen pressure (PaO2)). Healthy volunteers will be monitored and blood and urine will be obtained at 24h and 48 hours after returning to normoxia.

Healthy Volunteers

To create the correct gas mixture, nitrogen tanks or membrane technology nitrogen generators will be utilized.
Humidified, high flow, hypoxic gas by nasal cannula will allow the participant to walk short distances, eat, execute basic personal needs (e.g., use of toilette, washing, bathing etc.), or take breaks from wearing the mask.

Inhaled Nitrogen

Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation.

Hypoxia as a therapy for mitochondrial disease.

Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial.

Massachusetts General Hospital

Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

Physiological and Biochemical Response to Prolonged Exposure to Hypoxic Breathing in Healthy Volunteers

Peripheral oxygen saturation of the healthy volunteers receiving different levels of FiO2 will be continuously monitored for the 5 days of hypoxia titration and the 2 days after return to normoxia.

Erythropoietin will be tested each day during the 7 day study period.

Pulmonary pressure will be non-invasively measured via transthoracic echocardiography each day during the 7 day study period.

Plasma reactive oxygen species (ROS) will be evaluated each day during the 7 day study period.

Venous acid-base status will be evaluated each day during the 7 day study period.

Systemic blood pressure will be regularly monitored during the 7 day study period.

Heart rate will be continuously monitored via electrocardiography (EKG) during the 7 day study period.

Respiratory rate will be regularly monitored during the 7 day study period.

Lactate levels will be tested each day during the 7 day study period.

Alpha-hydroxybutyrate levels will be tested each day during the 7 day study period.

subarachnoid hemorrhage/fatigue

Study of Anlotinib Plus Chemoradiotherapy in Patients With Locally Advanced NSCLC

Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.

Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

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