Individuals included in the First Episode Psychosis Clinical Program (PAFIP) between June 2011 and February 2016.
Retrospective study of frozen samples: samples at baseline and 3 months will be analyzed.

Individuals included in the First Episode Psychosis Clinical Program (PAFIP) between September 2016 and September 2017.
Prospective study of fresh samples: samples at baseline and 3 months will be analyzed.

Healthy subjects without psychotic disorder.

Serum and peripheral blood mononuclear cell (PBMC)

Schizophrenia

Mental Disorders

Psychotic Disorders

Frozen samples of serum and peripheral blood mononuclear cell (PBMC) stored in the Biobank Valdecilla will be selected.

Retrospective study of frozen samples

Samples of serum and cells will be drawn.

Prospective study of fresh samples

University Hospital Marqués de Valdecilla

Study of the Activation of Proinflammatory Pathways of Toll-like Receptors in Schizophrenia Patients

Retrospective and Prospective Study of the Activation of Proinflammatory Pathways of Toll-like Receptors in Patients With Schizophrenia: a Comparative Effect of Risperidone vs Aripiprazole

The Milliplex Human High Sensitivity T Cell Magnetic Bead Kit will be used to analyze the proinflammatory molecules. This kit includes response cytokines (Th1, Th2, Th17 and regulatory) and cytokines secreted by macrophage cells and myeloid lineage. It allows a balance of pro and anti-inflammatory cytokines.
Luminex is an automated flow cytometer with an open technology that allows various tests to measure different biological parameters, reducing time, handling and cost overruns compared to more traditional methods such as Western Blot, enzyme-linked immunosorbent assay (ELISA) or traditional protein arrays. The methodology uses tests in the microsphere surface or magnetic beads of 5.6 um diameter which emit fluorescence and it is detected in a compact analyzer (Luminex).

The Mitogen-Activated and Stress-Activated Protein Kinase (MAPK/SAPK) Signaling Magnetic Bead Kit will be used to detect changes in the lysates of frozen cells of the following proteins: phosphorylated Extracellular Signal-Regulated Kinase (ERK)/MAPK 1/2 (Thr185/Tyr187), STAT1 (Tyr701), Jun Amino-terminal Kinases (JNK) (Thr183/Tyr185), Mitogen-activated protein Kinase kinase 1 (MEK1) (Ser217/221), Mitogen- and Stress-activated protein Kinase 1 (MSK1) (Ser212), Activating Transcription Factor-2 (ATF2) (Thr71), p53 (Ser15), HSP27 (Ser78), c-Jun (Ser73) and p38 (Thr180/Tyr182). This method is a fast and very useful alternative and it is more objective than the Western Blot and conventional immunoprecipitation.

Cells respond to stimuli from the microenvironment by activation of intracellular signaling cascades. Many of these stimuli are transmitted via receptors having in their intracellular domain tyrosine kinases which promote cell metabolism and his growth. Many of these signals activate Ser / Thr kinases signals, whose intermediaries are p70 S6 kinase, MSK1, Signal Transducers and Activators of Transcription (STATs) and Cyclic adenosine monophosphate Response Element-Binding protein (CREB). On the other hand, the danger signals and cell death can promote other signaling pathways such as p38, JNK and p53.

To assess whether it can predict the disease progression based on immune activation (quantization the levels of proinflammatory molecules) in the first psychotic episode.

Benedicto Crespo-Facorro

Professor of Psychiatry

Fundación Marques de Valdecilla

Centro de Investigación Biomédica en Red de Salud Mental

Instituto de Investigación Marqués de Valdecilla

flecainide x 6 months, then crossover to sotalol x 6 months

sotalol x 6 months, then crossover to flecainide x 6 months

Atrial Fibrillation

flecainide up to 150mg twice daily for the control of atrial fibrillation

Flecainide

sotalol up to 120mg twice daily for the control of atrial fibrillation

Sotalol

Jesse Brown VA Medical Center

Rush University Medical Center

University of Illinois at Chicago

Advocate Christ Medical Center

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs

Subjects will be monitored with the Medtronic Reveal LINQ Insertable Cardiac Monitor (ICM) system to assess AF burden. The device will be programmed to optimize the memory for storing AF episode..

Quality of life assessment: Patients will be asked to fill out the AFEQT quality of life questionnaire baseline (study randomization), two, four, six, eight, ten, and 12 months (completion of the study). The questionnaire at the end of the 6rd month will be administered just prior to stopping the first study drug. The validated questionnaire is comprised of 20 questions about AF symptoms with answers given on a Likert scale. The questionnaire will be provided to the patients in paper format either in person or by mail, as applicable. A follow-up phone call will be made to each patient to ensure that the questionnaire is completed and returned.

vasculitis/köklük

Study of the Activation of Proinflammatory Pathways of Toll-like Receptors in Schizophrenia Patients

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

Lupus Cohort--Thrombotic Events and Coronary Artery Disease

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