Yerba Mate Extract - Capsules: daily dose of 2.250 g, distributed in 3 doses of 750 mg, for 28 days.

Starch - Capsules: 3 times daily for 28 days.

Cardiovascular Disease

Diabetes

Yerba Mate Extract

Take 3 capsules, 3 times daily for 28 days.

Placebo

Euclides Lara Cardozo Júnior

Yerba Mate (Ilex Paraguariensis A.St.-Hil.): Assessment of Cardiovascular Health

Application of Yerba Mate (Ilex Paraguariensis A.St.-Hil.) Products on the Promotion of Health: Assessment of Cardiovascular Health

Cholesterol - Enzymatic colorimetric method; HDL cholesterol - lipoproteins VLDL (very low density lipoprotein) and LDL (Low Density Lipoprotein) and chylomicrons are precipitated with a mixture of phosphotungstic acid and magnesium chloride. After centrifugation, the bound cholesterol to high density lipoproteins (HDL) in the supernatant determined by colorimetric enzymatic method; Triglycerides - Enzymatic colorimetric method; Fasting glucose - enzymatic colorimetric method.
All results are expressed in mg / dL.

C-reactive protein (CRP) - Kit using turbidimetric methods for the quantitative

Endothelin (EDN-1) - using enzyme immunoassay kit (ELISA) for the quantification in vitro EDN-1 in human serum. Evaluation kit for using enzyme immunoassay technique (ELISA) for the quantitative in vitro determination of ICAM-1 and VCAM-1 in human serum. The results of analyzes are expressed in ng/ml.

Interleukin-6 (IL-6) - Evaluation kit for using enzyme immunoassay technique (ELISA) for the quantitative determination of IL-6 in vitro in human serum. The results of analyzes for IL-6 are expressed in ng/ml.

Oral Glucose Tolerance Test OGTT (in mg/dL). A standard anhydrous glucose load will be administered and evaluation of Oral Glucose Test Tolerance (OGTT) after consumption of a high sugar load.

Profile Evaluation of leukocyte gene expression through nutrigenomics study after consumption capsules containing standardized amount of yerba mate. The genes involved in lipid metabolism are isolated, identified and quantitated by real-time PCR technique. The results are expressed according to the identification and the number of genes.

Karimi Sater Gebara

Master

Institut National de la Recherche Agronomique

A20-50 (2 capsules). Each capsule contains:
Yerba Mate (Ilex paraguariensis), Guarana seed (Paullinia cupana), Magnesium Oxide , Caffeine , Damiana (Turnera microphylla), Green tea (Camellia sinensis), Ginger (Zingiber Officinale), Kola nut (Cola acuminate or nitida), Pyridoxine Hydrochloride, Tibetan Ginseng root (Rhodiola crenulata), Schisandra (Schisandra Chinensis), Jujube (Ziziphus Jujuba) , Cocoa nut (Theobroma cacao), Chinese Skullcap (Scutellaria Baicalensis), Black tea leaf (Thea sinensis), Rice flour (to fill)
Dose = 2 capsules have a total of 200 mg of caffeine

YGD blend (2 capsules). Each capsule contains:
Yerba Maté (leaf) , Guarana (seed) , Damiana (leaf) , Rice flour: to fill ,
The 2 capsules of the YGD blend contain about 40 mg xanthines (caffeine and caffeine-like stimulants).

Placebo (2 capsules). Each capsule contains:
Rice Flour

Obesity

3-arm crossover study for investigation of the effect of herbal supplements A20-50 compared to YGD blend and placebo on subjective appetite sensations, glucose, insulin, ghrelin, GLP-1, CCK and ad libitum energy intake

Appetite suppressant properties of YGD and A20-50

Department Of Human Nutrition, Faculty of Science, University of Copenhagen

Appetite Suppression Effects of an Herbal Combination of Yerba maté, Guarana, Damiana (YGD), and 12 Other Herbal Components, Versus YGD Supplementation Alone

Assessment of subjective appetite sensations (visual analogue scales (VAS)) at time 0 (baseline - prior to the test meal) and at time 30, 45, 60, 90, 120, 150, 180 and 240 minutes post intake.
Measured subjective appetite sensations of hunger, satiety, prospective consumption, fullness, composite appetite score.

Assessment of subjective appetite sensations (visual analogue scales (VAS)) at time 0 (baseline - prior to the test meal) and at time 30, 45, 60, 90, 120, 150, 180 and 240 minutes post intake.
Measured subjective sensory desires for something sweet, salty, rich in fat, or meat/fish

A venflon catheter was secured into the participants' antecubital vein, and a blood sample was taken (baseline). Immediately after the subjects were served the test compound (2 capsules). Blood samples were taken at 15 and 30 minutes after intake of the test compound (2 capsules). After 30 minutes post test compound consumption (time 0), the subjects were given a standard breakfast (2.0 MJ: bun with cheese, yoghurt, 200 ml orange juice). Additional blood samples were taken 15, 30, 45, 60, 90, 120, 150, 180 and 240 minutes post-meal

240 min after each test meal an ad libitum meal was served, and the total energy intake was recorded

After completion of the adlibitum meal the subjects will rate the organoleptic quality of the meal by visual analogue scales (VAS) in regard to appearance, smell, taste, after-taste, and general palatability.

After completion of the ad libitum meal the subjects will rate the subjective appetite sensations by visual analogue scales (VAS) in regard to sensation of hunger, satiety, prospective consumption, fullness, composite appetite score and sensory desires to eat something sweet, salty, rich in fat, or meat/fish.

body weight will be measured to the nearest 0.05 kg on a decimal scale.

heart rate were measured using an automatically inflating cuff.

blood pressure were measured using an automatically inflating cuff.

Body composition will be assessed by electric bioimpedance using an Animeter.

Arne Astrup

Professor, Dr Med

University of Copenhagen

Subjects will drink 1000ml/day of yerba mate tea for 8 weeks.

Subjects will drink 1000ml/day of green tea for 8 weeks.

Subjects will drink 1000ml/day of apple tea for 8 weeks.

Dyslipidemia

Inflammation

Before and after 8 weeks, serum lipids, C-reactive protein and fibrinogen will be measured. They will also be tested for glycemia, insulin, aminotransferases, bilirubin. Anthropometric measurements will be also performed at week 0 and 8. The subjects will receive instructions to maintain their usual dietary intake and normal physical activity.

yerba/köklük

Yerba Mate (Ilex Paraguariensis A.St.-Hil.): Assessment of Cardiovascular Health

Appetite Suppression Effects of an Herbal Combination of Yerba maté, Guarana, Damiana (YGD), and 12 Other Herbal Components, Versus YGD Supplementation Alone

Cardioprotective Effects of Green Tea Versus Maté Intake

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