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Noninvasive Fluorine-19 Magnetic Resonance Relaxometry Measurement of the Partial Pressure of Oxygen in Acellular Perfluorochemical-loaded Alginate Microcapsules Implanted in the Peritoneal Cavity of Nonhuman Primates.

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We have utilized a noninvasive technique for measuring the partial pressure of oxygen (pO2) in alginate microcapsules implanted intraperitoneally (i.p,) in healthy non-human primates (NHPs). Average pO2 is important for determining if a transplant site and capsules with certain passive

19F-MRI in vivo determination of the partial oxygen pressure in perfluorocarbon-loaded alginate capsules implanted into the peritoneal cavity and different tissues.

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Semipermeable hydrogels formed with a biocompatible alginate solution and Ba(2+) ions protect encapsulated cells and tissues from a foreign immune system. For the viability and metabolic activity of the encapsulated materials, a sufficient oxygen supply inside the capsules is necessary. Quantitative

Cancer stem cell marker-expressing cell-rich spheroid fabrication from PANC-1 cells using alginate microcapsules with spherical cavities templated by gelatin microparticles.

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Cancer stem-like cells (CSCs) are rare subpopulations of cancer cells. The development of three-dimensional tissues abundant in CSCs is important to both the understanding and establishment of novel therapeutics targeting them. Here, we describe the fabrication of multicellular tumor spheroids

Alginate-caseinate based pH-responsive nano-coacervates to combat resistant bacterial biofilms in oral cavity.

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Biofilm associated microbial resistance is a major concern in oral health and hygiene. Nano-antimicrobials (NAMs) having natural antibiotic replacers e.g. nisin are the possible solution to treat oral infections. In this study, we have developed pH responsive, mucoadhesive protein-polysaccharide

Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient.

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OBJECTIVE Alginate-encapsulated human islet cell grafts have not been able to correct diabetes in humans, whereas free grafts have. This study examined in immunodeficient mice whether alginate-encapsulated graft function was inferior to that of free grafts of the same size and

Use of calcium alginate to pack abscess cavities: a controlled clinical trial.

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Many conventional dressings are painful when removed, and may be detrimental to healing. In a pilot study ten consecutive abscesses, requiring incision and drainage, were packed with a calcium alginate dressing: this was well tolerated, its removal causing minimal pain. No adverse effects were

Effect of topical application of alginate containing fluoride or fluoride and chlorhexidine on dental caries in rats.

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[Effect of acid etching of retropreparation cavities on seal of retrofill materials].

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OBJECTIVE To evaluate the effect of acid etching of retropreps on seal of different retrofill materials. METHODS In the study, 80 freshly extracted lower molar teeth were used. They were examined under 3.5× magnifying glass to rull out fractures. They were cleaned and stored in distilled water

Comparison of methods for the sampling and isolation of toxigenic Pasteurella multocida from the nasal cavity of pigs.

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The efficacy of detecting toxigenic Pasteurella multocida from nasal swabs of slaughtered and live pigs was assessed. The isolation of toxigenic P multocida from nasal cavities of slaughtered bacon pigs from two herds with atrophic rhinitis was reduced by immersion in the hot water tank by 25 per

Assessment of the Relationship Between Facial and Dental Midlines with Anatomical Landmarks of the Face and Oral Cavity.

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The purpose of the present study was to determine the facial anatomical landmarks, in order of accuracy, closest to the midline of the face, as well as oral cavity midline, and to specify which intraoral anatomical landmarks are closer to the dental

Effect of the alginate composition on the biocompatibility of alginate-polylysine microcapsules.

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Alginate-polylysine (PLL) capsules are commonly applied for immunoprotection of endocrine tissues. Alginate is composed of mannuronic acid (M) and guluronic acid (G). Different types of alginate have different ratios of G to M, but little is known of the influence of these differences on

Factors influencing alginate gel biocompatibility.

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Alginate remains the most popular polymer used for cell encapsulation, yet its biocompatibility is inconsistent. Two commercially available alginates were compared, one with 71% guluronate (HiG), and the other with 44% (IntG). Both alginates were purified, and their purities were verified. After 2

Reversible Mechanical Regulation and Splicing Ability of Alginate-Based Gel Based on Photo-Responsiveness of Molecular-Level Conformation.

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In this study, benefiting from the sensitive molecular conformation transversion in azobenzene, a new strategy for fabricating alginate gels with the abilities of splicing and photo-responsive mechanical adjustment is reported. Firstly, a 4,4'-azobis(benzoylhydrazide) (Azo-hydrazide) linker was used

Evaluation of bioartificial pancreas function made from sodium alginate and poly-L-lisine microcapsules settled with viable pancreatic islets.

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The possibility of transplantation of immuno-isolated viable pancreatic islets is a promising alternative for treatment diabetic patients. To establish the value of the artificial prosthesis made from settled with viable pancreatic islets microcapsulated using sodium alginate and poly-L-lisine, the

Bioluminescence tracking of alginate micro-encapsulated cell transplants.

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Cell-based therapies to treat loss-of-function hormonal disorders such as diabetes and Parkinson's disease are routinely coupled with encapsulation strategies, but an understanding of when and why grafts fail in vivo is lacking. Consequently, investigators cannot clearly define the key factors that

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