arnold-chiari malformation/хипоксия

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Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor.

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The relationship between tumor oxygenation and the effectiveness of photodynamic therapy (PDT) was studied in vitro and in vivo using the RIF mouse tumor model. The oxygen dependence of photodynamic inactivation of RIF cells, which had been exposed to 25 mg/kg porphyrin (dihematoporphyrin ether) in

The blood acid-base changes in acute cyanide poisoning in the rat in comparison with those in acute anoxic anoxia: with special reference to the relation with the time to death.

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Rats were given orally various doses of NaCN (20,15,10, and 7 mg of CN per kg). When respiration stopped, the chest was opened and heart blood was taken anaerobically, and blood acid-base, lactate, and glucose determinations were made. As a control to chemical anoxia by cyanide, indentical

Hypoxemia reflexly increases secretion from tracheal submucosal glands in dogs.

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We anesthetized dogs, ventilated their lungs via the lower trachea, and exposed the epithelial surface of the upper trachea and coated it with powdered tantalum. Secretions from submucosal gland ducts formed elevations (hillocks) in the tantalum layer; we counted the number of hillocks that appeared

Adhesion of flowing monocytes to hypoxia-reoxygenation-exposed endothelial cells: role of Rac1, ROS, and VCAM-1.

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Production of reactive oxygen species (ROS) by ischemic tissue after ischemia-reperfusion (I/RP) is an important factor that contributes to tissue injury. The small GTPase Rac1 mediates the oxidative burst, and ROS act on signaling pathways involved in expression of inflammatory genes. Because there

Neonatal hypoxia: long term effects on pulmonary arterial muscle.

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The purpose of this study was to determine if neonatal hypoxia alters pulmonary arterial smooth muscle (PASM) function in young adult rats. One day old rats were made hypoxic (FIO2 = 0.1) for 5 days, then maintained under normoxic conditions until young adulthood (45-50 days). Age-matched rats were

Maturation alters the pulmonary arterial response to hypoxia and inhaled nitric oxide in the presence of endothelial dysfunction.

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Surgical intervention in ever younger patients has led to a new appreciation of the unique physiology of the neonate. Specifically, newborn patients may respond very differently to hypoxic episodes and subsequent treatment with inhaled nitric oxide than older infants. In the current study, we

Activation of mammalian target of rapamycin induces lipid accumulation in the diaphragm of ventilated rats and hypoxia-treated C2C12 cells.

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BACKGROUND Our previous study demonstrated that ventilators increase diaphragmatic lipid accumulation in rabbits, but their cellular mechanism is poorly understood. Mammalian target of rapamycin (mTOR) plays an important role in atherosclerosis in rat vascular smooth muscle cells. The present study

[Reaction of rats to the effect of hyperbaric oxygenation after preliminary adaptation to hypoxia].

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Preliminary adaptation of rats to hypoxia in the regimen exceeding the resistance to many stress agents not only produced no protective effect in response to the action of increased oxygen pressure (IOP) up to 6 kg/cm2, but, on the contrary, decreased the organism resistance. Thus, the time of

Therapeutic ultrasound protects HUVECs from ischemia/hypoxia-induced apoptosis via the PI3K-Akt pathway.

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Background: Previous studies have demonstrated that therapeutic ultrasound (TUS) ameliorates angiogenesis on ischemic hind limb animals and also promotes human umbilical vein endothelial cells (HUVECs) tube formation. Apoptosis plays a key role in post-ischemic angiogenesis pathogenesis. However,

Effect of hypoxia upon the growth and sprouting activity of cultured aortic endothelium from the rat.

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Endothelial cells were obtained from the aortas of Wistar rats by collagenase digestion. Cells were grown to confluence in medium 199 enriched with L-glutamine but without specific growth factors. Cells were subcultured into 35 mm dishes or 25 cm2 flasks coated with fibronectin. For cell growth

Suppression of myometrial contractile responses to oxytocin after different durations of chronic hypoxia in the near-term pregnant rat.

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OBJECTIVE In light of our previous finding that chronic hypoxia decreases the myometrial contractile response to oxytocin in the near-term pregnant rat, we designed the current study (1) to investigate the effect of duration of hypoxic exposure on the contractile response to oxytocin and oxytocin

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

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Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF), an endothelial cell (EC)-specific mitogen, stimulates angiogenesis in vivo, particularly in ischemic regions. VEGF/VPF expression by cells of hypoxic tissues coincides with expression of its two receptors, KDR and flt-1,

Analysis of cable properties under hypoxia in cardiac muscles.

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This study was undertaken to determine the effect of hypoxia on the cable properties of the canine ventricular muscle, employing a single sucrose gap method. Hypoxia caused the internal longitudinal resistance, Ri, to increase by 25% (P smaller than 0.02) and the length constant, lambda, to decrease

Hypoxia-induced contractions of porcine pulmonary artery strips depend on intact endothelium.

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Experiments were carried out to test the hypothesis that intact endothelium is required for hypoxia-induced contractions of pulmonary vascular muscle in vitro. To study this possibility, we cut pairs of transverse strips from main pulmonary arteries of pigs, removed the endothelium from one strip,

Colon epithelial electrical responses to acute hypoxia and reoxygenation in vitro.

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Electrogenic epithelial transport depends on oxidative metabolism. Acute hypoxia and subsequent reoxygenation effects on short-circuit current (Isc), transepithelial potential difference (PD) and tissue resistivity (TR) of rat distal colon were assessed. The tissue was mounted in an Ussing chamber

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