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Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry.

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A novel metabonomic method based on fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC/MS-IT-TOF) was applied to study the metabolic changes of plasma and urine in depression and excess fatigue rats. Principal component analysis (PCA) and partial least

[B-chronic lymphocytic leukemia/prolymphocytic leukemia (CLL/PL)--a case report].

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A 48-year-old male was admitted to our hospital on April 20, 1989 because of general fatigue and abdominal fullness. Physical examination showed hepatomegaly, massive splenomegaly, and systemic lymphadenopathy. Hematological findings revealed WBC 73,000/microliters, RBC 289 x 10(4)/microliters, Hb

Ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease.

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Chronic obstructive pulmonary disease (COPD) is associated with systemic oxidative stress and skeletal muscle dysfunction. The purpose of this study was to examine the impact of intravenous ascorbate administration (AO) on biological markers of antioxidant capacity and oxidative stress, and

Oxidative stress and COPD: the effect of oral antioxidants on skeletal muscle fatigue.

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OBJECTIVE Oxidative stress may contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). This study sought to determine the effect of an acute oral antioxidant cocktail (AOC, vitamins C and E, and alpha-lipoic acid) on skeletal muscle function during dynamic

The Effect of Carbohydrate Beverage Ingestion on Central versus Peripheral Fatigue: A Placebo-Controlled, Randomized Trial in Cyclists.

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OBJECTIVE We investigated whether carbohydrate ingestion delays fatigue in endurance-trained cyclists via peripheral or central mechanisms. METHODS Ten men [35±9 yrs] and ten women [42±7 yrs] were assigned, in a double-blind, cross-over design to a sports drink [CHO] and placebo [PL]. Strength

Acute beetroot juice supplementation does not attenuate knee extensor exercise muscle fatigue in a healthy young population.

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The effect of acute nitrate supplementation on muscle fatigue is largely unknown. This study aimed to evaluate the effect of acute nitrate supplementation on muscle fatigue.Thirty-five recreationally active subjects consumed 140 ml of beetroot (BR) juice

Forearm muscle metabolism studied using (31)P-MRS during progressive exercise to fatigue after Acz administration.

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The effects of acetazolamide (Acz)-induced carbonic anhydrase inhibition (CAI) on muscle intracellular thresholds (T) for intracellular pH (pH(i)) and inorganic phosphate-to-phosphate creatine ratio (P(i)/PCr) and the plasma lactate (La(-)) threshold were examined in nine adult male subjects

Effects of creatine loading on electromyographic fatigue threshold in cycle ergometry in college-age men.

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The purpose of this study was to examine the effects of 5 d of creatine (Cr) loading on the electromyographic fatigue threshold (EMG FT) in college-age men. Sixteen men (age 22.4 +/- 2.6 yr, height 177.4 +/- 6.8 cm, weight 79.5 +/- 10.6 kg; M +/- SD) participated in this double-blind study and were

A laboratory approach for characterizing chronic fatigue: what does metabolomics tell us?

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Manifestations of fatigue range from chronic fatigue up to a severe syndrome and myalgic encephalomyelitis. Fatigue grossly affects the functional status and quality of life of affected individuals, prompting the World Health Organization to recognize it as a chronic non-communicable

Post-Lyme syndrome and chronic fatigue syndrome. Neuropsychiatric similarities and differences.

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BACKGROUND Patients with chronic fatigue syndrome (CFS) and post-Lyme syndrome (PLS) share many features, including symptoms of severe fatigue and cognitive difficulty. OBJECTIVE To examine the neuropsychiatric differences in these disorders to enhance understanding of how mood, fatigue, and

Methylphenidate and/or a nursing telephone intervention for fatigue in patients with advanced cancer: a randomized, placebo-controlled, phase II trial.

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OBJECTIVE Cancer-related-fatigue (CRF) is common in advanced cancer. The primary objective of the study was to compare the effects of methylphenidate (MP) with those of placebo (PL) on CRF as measured using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) fatigue subscale. The

A confirmatory factor analysis for an adapted and validated Polish version of the <i>Chalder Fatigue Questionnair</i>e.

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The<i> Chalder Fatigue Questionnaire</i> (CFQ) was developed to measure fatigue in 2 dimensions: physical and mental. The aim of the study was to translate, adapt and evaluate the psychometric properties of the Polish version of the CFQ

The impact of physical activity on fatigue and quality of life in lung cancer patients: a randomised controlled trial protocol.

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BACKGROUND People with lung cancer have substantial symptom burden and more unmet needs than the general cancer population. Physical activity (PA) has been shown to positively influence quality of life (QOL), fatigue and daily functioning in the curative treatment of people with breast and

Acute ibuprofen ingestion does not attenuate fatigue during maximal intermittent knee extensor or all-out cycling exercise.

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OBJECTIVE Recent research suggests that acute consumption of pharmacological analgesics can improve exercise performance, but the ergogenic potential of ibuprofen (IBP) administration is poorly understood. This study tested the hypothesis that IBP administration would enhance maximal exercise

The EORTC QLQ-C15-PAL questionnaire: validation study for Spanish bone metastases patients.

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OBJECTIVE Quality of life (QL) is a key outcome for advanced disease cancer patients. The European Organization for Research and Treatment of Cancer (EORTC) has developed the QLQ-C15-PAL questionnaire, a short version of the QLQ-C30 for palliative care. The aim of the present study is to validate

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