[Hepatoprotective effect of Gossipium hirsutum extract on acute experimental hepatitis on rat liver injury].

OBJECTIVE

To investigate the protective effect on the mice acute experimental hepatic injury by Flos Gossypium herbaceum extracts (FGF-I, FGF-II).

METHODS

Experimental hepatic injury model was established by a single intraperitoneal injection of 350 mg x kg(-1) D-CalN in Wistar rats. Serum samples for alanine aminotransferase (ALT), aspartate transferase (AST) level and liver homogenate samples for super oxide dismutase (SOD), malondialdehyde (MDA), Glutathione peroxidese (GSH-PX) activities were assayed.

RESULTS

For acute experimental hepatic injury, FGF-I and FGF-II significantly decrease the serum transaminase activities (P < 0.01). FGF-I increased the SOD activities (P < 0.01), and decreased MDA content only for 50 mg x kg(-1) FGF-I (P < 0.05), no effect on GSH-PX activity was found for them. FGF-II increased the SOD and GSH-PX activity (P < 0.05) with decreased MDA content (P < 0.05).

CONCLUSIONS

FGF-I and FGF-II showed significant protective action in mice experimental hepatic injury.