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8 resultater
Proteomic analysis of aqueous humor from patients with myopia.
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OBJECTIVE
The mechanism of axial elongation in the myopic eyeball remains to be elucidated. It is known that the expression profile for some proteins in the aqueous humor (AH) changes in some diseases. Accordingly, determinations of these AH proteins may serve to understand their potential role in
Choroidal regulation of scleral glycosaminoglycan synthesis during recovery from induced myopia.
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OBJECTIVE
The present study was undertaken to examine the relationship between choroidal permeability and scleral glycosaminoglycan synthesis rates during the development of and recovery from form deprivation myopia.
METHODS
Form deprivation myopia was induced in chicks for 10 days and was followed
The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs.
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OBJECTIVE
To investigate whether the Sonic hedgehog (Shh) signaling induces myopic development by increasing the expression of matrix metalloproteinase (MMP)-2 in guinea pigs.
METHODS
A translucent diffuser was glued onto the right eye to induce form-deprivation myopia (FDM) in 10 guinea pigs. Four
The correlation between the regulation of recombinant human IGF-2 on eye growth and form-deprivation in guinea pig.
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OBJECTIVE
By investigating the effects of recombinant human IGF-2 (rhIGF-2) on the diopter, axial eye length and the expression of IGF-2 in non-form-deprivation (FD) and FD eyes of guinea pig, we tried to elucidate the relationship between the effects of rhIGF-2 on eye growth and FD in guinea
Immediate changes in protein-concentration in aqueous humor induced by intracapsular lens extraction in human eyes.
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In 71 patients that underwent intracapsular extraction of the cataract it was possible to collect aqueous humor (a.h.) in sufficient quantities at the beginning and at the end of the operation. Using radial immunodiffusion albumin, IgG and alpha-1-antitrypsin were measured in the samples. In
Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: the DCCT/EDIC Study
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Objective: Determine relationship between refractive error and diabetic retinopathy (DR).
Design: Clinical trial SUBJECTS: Myopia is a non-modifiable risk factor reportedly
The blood-aqueous barrier and its permeability for proteins of different molecular weight.
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In aqueous humors and sera from 44 patients with cataracts, albumin, IgG, and alpha-1-antitrypsin were measured using radial immunodiffusion. The mean concentrations of the three proteins were significantly smaller than values found in aqueous humors taken post mortem, but corresponded well to
In-depth phenotyping of a Donnai-Barrow patient helps clarify proximal tubule dysfunction.
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BACKGROUND
The megalin/cubilin/amnionless complex is essential for albumin and low molecular weight (LMW) protein reabsorption by renal proximal tubules (PT). Mutations of the LRP2 gene encoding megalin cause autosomal recessive Donnai-Barrow/facio-oculo-acoustico-renal syndrome (DB/FOAR), which is
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