colchicine/edema

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Mechanism of action of colchicine. I. Effect of colchicine and its analogs on the reversed passive Arthus reaction and the carrageenan-induced hindpaw edema in the rat.

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Colchicine and N-desacetyl-N-methylcolchicine suppressed both the reversed passive Arthus reaction and the carrageenan-induced edema in the rat. Colchicine, 2-desmethyl-colchicine glucoside and trimethylcolchicine acid had no effect on either model of inflammation. The ability or inability of these

Case report: acute hydrops and spontaneous corneal perforation in a patient with keratoconus treated with colchicine for familial Mediterranean fever.

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OBJECTIVE To report a rare case of spontaneous corneal perforation after hydrops in keratoconus patients who suffer from familial Mediterranean fever and was treated systemically with Colchicine. METHODS Case report. RESULTS We report a case of a 30-year-old male with keratoconus and familial

Inhibition of sodium urate-induced rat hindpaw edema by colchicine derivatives: correlation with antimitotic activity.

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Dopamine restores lung ability to clear edema in rats exposed to hyperoxia.

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Exposure to hyperoxia causes lung injury, decreases active sodium transport and lung edema clearance in rats. Dopamine (DA) increases lung edema clearance by stimulating vectorial Na+ flux and Na, K-ATPase function in rat alveolar epithelium. This study was designed to test whether DA (10(-)5 M)

Colchicine-estrogen interactions.

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Colchicine does not block estrogen-induced recognition of uterine blood vessel surface by eosinophils, but interfers with their migration through endothelial lining and therefore blocks estrogen-induced uterine eosinophilia and edema.

Colchicine against ischemia-reperfusion injury in experimental lung transplantation.

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BACKGROUND To asses the influence of colchicine, a potent antinflammatory agent and neutrophile migration inhibitor, on Ischemia-Reperfusion Injury (IRI) in rat lung isogeneic transplantation. METHODS Isogeneic, orthotropic single left lung transplantations were performed among male Wistar rats

Mesothelioma in Familial Mediterranean Fever With Colchicine Intolerance: A Case Report and Literature Review

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A 65-year-old Italian physician affected by Familial Mediterranean fever (FMF) was hospitalized due to progressive abdominal enlargement, which had begun 6 months before admission. Physical examination revealed ascites and bilateral leg edema. Abdominal CT scan showed ascitic fluid and extensive

Colchicine in the treatment of the inflammatory phase of Graves' ophthalmopathy: a prospective and randomized trial with prednisone.

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OBJECTIVE To investigate if colchicine is valuable in the treatment of Graves' ophthalmopathy (GO), we compared its effect with prednisone in 22 patients during the inflammatory phase of GO. METHODS All patients, similar in age, sex and smoking habits, were euthyroid for at least 3 months and

Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties.

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We have developed a new series of immunosuppressant with improved pharmacokinetic properties as the second-generation of colchicine analogs, which were designed based on the privileged structure derived from our previous work. In particular, we identified an analog (14), which exhibited a potent in

[Morphologic indices of the rat heart after colchicine application to the vagus nerve].

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By means of the light optic and electron microscopic methods atrial ganglia, myocytes, vessels of the right cardiac chambers have been studied in rats 2 days--3 weeks after application of 100 mcg of colchicine on the right nervus vagus. Certain changes of the neural fibers have been described at the

Coexistence of hereditary angioedema in a case of familial Mediterranean fever with partial response to colchicine.

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Hereditary angioedema (HAE) is a very rare and potentially life-threatening genetic disease characterised by episodes of edema in various parts of the body, including the extremities, face, and airway. The disease is usually associated with attacks of abdominal pain. On the other hand, familial

Survival of a dog with accidental colchicine overdose.

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To describe the treatment and clinical course of a dog accidentally prescribed 10 times the recommended dose of colchicine (0.3 mg/kg/d instead of 0.03 mg/kg/d).After glaucoma surgery, a 1-year-old male neutered Pomeranian weighing 6.8 kg was prescribed

The endolymphatic sac and inner ear homeostasis. II: Effect of glycerol on the sensory end organs with or without colchicine pretreatment.

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The effects of glycerol and colchicine on the sensory end organs of the inner ear were investigated in mice. Glycerol alone induced a widening of the intercellular spaces lining vestibular dark and transitional cells as well as the marginal cells of the stria vascularis. This was noted within 30 min

Cytochalasin D induces edema formation and lowering of interstitial fluid pressure in rat dermis.

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The increased capillary fluid filtration required to create a rapid edema formation in acute inflammation can be generated by lowering the interstitial fluid pressure (P(IF)). The lowering of P(IF) appears to involve dynamic beta(1)-integrin-mediated interactions between dermal cells and

[Secondary amyloidosis in ulcerative colitis--successful treatment with colchicine].

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A 20 year old male patient with a four-years-history of moderately active ulcerative colitis was admitted due to extensive generalized edema. He suffered from a nephrotic syndrome, which was caused by secondary renal amyloidosis due to the colitis. Under continuous low dose therapy with colchicine

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