folate/edema

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Homocysteine is linked to macular edema in type 2 diabetes.

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OBJECTIVE To explore the relationship between plasma total homocysteine concentration and diabetic macular edema in patients with type 2 diabetes. METHODS Patients with type 2 diabetes (n = 176) were enrolled in a cross-sectional hospital-based study. Diabetic macular edema status was documented by

Eyelid and feet edema induced by pemetrexed.

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Pemetrexed is an anti-metabolite that targets multiple enzymes in folate pathway. The main toxicities associated with pemetrexed are asthenia, nausea, diarrhea, myelosuppression, and rash. Few cases of pemetrexed induced cutaneous adverse event have been reported, mainly periorbital-facial edema and

Relapsing neuropathy, cerebral atrophy and folate deficiency. A close association.

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The case of a 48-year-old woman with a relapsing radial palsy which followed diarrheic episodes is reported. She had low folate concentrations in serum and cerebrospinal fluid, as well as low and borderline values of cerebrospinal fluid and erythrocyte folates. She had chronic gastrointestinal

Central pontine myelinolysis associated with acquired folate depletion.

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After long-standing malnutrition a 15-month-old boy with signs of kwashiorkor was admitted in a moribund state with serious hyponatraemic dehydration, hypothermia, somnolence, and signs of a pontine disconnection syndrome. Folic acid levels were below the detection level in the presence of normal

Chlorella pyrenoidosa supplementation reduces the risk of anemia, proteinuria and edema in pregnant women.

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Pregnancy anemia and pregnancy-induced hypertension (PIH) are common and potentially dangerous disorder in human pregnancy, and nutritional status of pregnant women is one of the leading causes. Chlorella contains large quantities of folate, vitamin B-12 and iron, and can help improve anemia and

Association of Genetics and B Vitamin Status With the Magnitude of Optic Disc Edema During 30-Day Strict Head-Down Tilt Bed Rest.

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Optic disc edema among astronauts after long-duration spaceflight is associated with 1-carbon pathway single-nucleotide polymorphisms and B vitamin status. A recent strict 6° head-down tilt bed rest (HDTBR) study documented development of optic disc edema and increased total retinal

Pemetrexed-induced edema of the eyelid.

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Pemetrexed is a novel antimetabolite that targets multiple enzymes in the folate pathway, and has exhibited clear antitumor activities in the treatment of malignant pleural mesothelioma and non-small cell lung cancer. Although many adverse events of pemetrexed, such as bone marrow suppression, have

Association of plasma homocysteine and macular edema in type 2 diabetes mellitus.

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OBJECTIVE The aim of this study was to assess the association of macular edema (ME) with plasma homocysteine, vitamin B6, vitamin B12, and folic acid levels in patients with Type 2 diabetes. METHODS Sixty-five diabetic subjects with no retinopathy and nonproliferative diabetic retinopathy (NPDR) (no

Plasma homocysteine levels are associated with macular thickness in type 2 diabetes without diabetic macular edema.

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OBJECTIVE To explore the relationships between macular thickness and the plasma concentrations of homocysteine, vitamin B12, folate, and other known risk factors for patients with diabetes without diabetic macular edema (DME). METHODS Fasting venous blood samples were collected from 252 subjects

Pemetrexed-Associated Eyelid Edema: Effective Treatment by Excision of Lymphedematous Eyelid Tissue.

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Pemetrexed is an antimetabolite agent that inhibits multiple folate-requiring enzymes and is used in the treatment of mesothelioma and non-small-cell lung cancer. One of its toxicities is isolated cutaneous swelling affecting the eyelids and/or orbit. The pathologic assessment or its management has

Pemetrexed-induced edema of the eyelids and scalp in a patient with metastatic lung cancer.

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Pemetrexed is an anti-metabolite that targets multiple enzymes in the folate pathway and it is indicated in the treatment of locally advanced or metastatic non-small cell lung carcinoma and malignant pleural mesothelioma. On September, 2008, the U.S. FDA (Food and Drug Administration) approved its

Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice.

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MOTS-c (mitochondrial open-reading-frame of the twelve S rRNA-c), a mitochondrial-derived 16-amino acid peptide, targets the methionine-folate cycle, increases 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) levels, and eventually activates AMP-activated protein kinase (AMPK). AMPK activation

Oral antidiabetic therapy in patients with heart disease. A cardiologic standpoint.

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Five types of oral antihyperglycemic drugs are currently approved for the treatment of diabetes: biguanides, sulfonylureas, meglitinides, glitazones, and alpha-glucosidase inhibitors. The cardiovascular effects of the most commonly used antidiabetic drugs in these groups are briefly reported, in an

Non-insulin antidiabetic therapy in cardiac patients: current problems and future prospects.

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Five types of oral antihyperglycemic drugs are currently approved for the treatment of diabetes: biguanides, sulfonylureas, meglitinides, glitazones and alpha-glucosidase inhibitors. We briefly review the cardiovascular effects of the most commonly used antidiabetic drugs in these groups in an

Klinefelter's syndrome presenting with leg ulcers.

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A 54-year-old man of Persian origin presented to our department with a 1-year history of ulcers on the right leg that had been unresponsive to numerous topical treatments, accompanied by lymphedema of the right leg. Medical history included hypergonadotropic hypogonadism, which had not been further

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