leiomyoma/proline

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Estrogen metabolite 2-methoxyestradiol induces apoptosis and inhibits cell proliferation and collagen production in rat and human leiomyoma cells: a potential medicinal treatment for uterine fibroids.

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OBJECTIVE The current study sought to investigate the effect of the estrogen metabolite 2-methoxyestradiol (2-MeOHE(2)) on apoptosis, cell proliferation, and collagen synthesis in human and rat leiomyoma cells. METHODS [(3)H] thymidine and [(3)H] proline incorporation studies were conducted. The

Mechanism of collagen biosynthesis up-regulation in cultured leiomyoma cells.

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Uterine leiomyoma is the most common tumour in women with a reported incidence of 25-30%. The tumors are benign, composed of smooth muscle cells with variable amount of collagen - rich fibrous tissue. It is well established that accumulation of extracellular matrix in leiomyoma is key feature of

[Histological and biochemical studies of collagen in human uterine leiomyomas].

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Forty eight human uteri including normal group (16 cases), adenomyosis group (5 cases) and myoma group (27 cases) were studied to clarify the pathogenesis of uterine leiomyomas on the viewpoint of the collagen metabolism. The leiomyomas in the myoma group were histologically divided into the three

Familial multiple cutaneous and uterine leiomyomas associated with papillary renal cell cancer.

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Multiple cutaneous and uterine leiomyomas is an autosomal dominant condition that results in benign smooth muscle tumours of the skin and, in females, uterine fibroids. This syndrome overlaps with hereditary leiomyomatosis and renal cell cancer syndrome in which affected individuals may develop the

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

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Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an inherited cancer syndrome linked to biallelic inactivation of the gene encoding the tricarboxylic acid cycle enzyme fumarate hydratase (FH). Individuals with HLRCC are at risk to develop cutaneous and uterine leiomyomas and an aggressive

The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis.

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The thyroid receptor interacting protein-6 (TRIP6) was first identified as a ligand-dependent binding partner for the thyroid hormone receptor in a yeast two-hybrid screen. A partial TRIP6 cDNA clone that was isolated in the initial screen encodes two copies of the LIM domain. The LIM domain is a

Roles of plasma proteins in the formation of silicotic nodules in rats.

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The contribution of plasma protein(s) to the stabilization of fibroids formed in rat lungs exposed to acute silica dust inhalation was examined. Antibodies against component proteins of the nodules remaining insoluble in 2% SDS, 10M urea and 40 mM sulfhydryl reagents under prolonged boiling

The concentrations of collagen-associated amino acids are higher in GnRH agonist-treated uterine myomas.

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OBJECTIVE To test the hypothesis that the effects of estrogen reduction on uterine leiomyoma regression are mediated through changes in cell density or the extracellular matrix. METHODS Uterine myomas were obtained from 20 women who had received randomly either the GnRH agonist leuprolide acetate

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