A polyclonal antibody against rat intestinal-type alkaline phosphatase (I-ALP) was generated and proven to be applicable immunohistochemically to paraffin-embedded sections. Expression of I-ALP in normal tissues, intestinal metaplasia and stomach tumors induced by
SAP-1 (stomach cancer-associated protein-tyrosine phosphatase-1) is a transmembrane-type protein-tyrosine phosphatase that is abundant in the brain and certain cancer cell lines. With the use of a "substrate-trapping" approach, p130(cas), a major focal adhesion-associated phosphotyrosyl protein, has
Stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1), a transmembrane-type protein-tyrosine phosphatase, is thought to inhibit integrin signaling by mediating the dephosphorylation of focal adhesion-associated proteins. Adenovirus-mediated overexpression of wild-type SAP-1, but not that
SAP-1 (stomach cancer-associated protein tyrosine phosphatase-1) is a transmembrane-type protein tyrosine phosphatase that has been implicated as a negative regulator of integrin-mediated signaling. The potential role of this enzyme in hepatocarcinogenesis has now been investigated by examining its
Ultracytochemical study was made of inosine diphosphatase (IDPase) and adenosine triphosphatase (ATPase) in the nuclei of normal epithelial and cancer cells of human gastric tumors. A new incubation medium for ultracytochemical demonstration of IDPase activity in the cell nuclei was developed. The
Post-translational modification of protein tyrosine phosphatases (PTPs) is implicated in functional modulation of these enzymes. Stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1), as well as protein tyrosine phosphatase receptor type O (PTPRO) and vascular endothelial-protein tyrosine
BACKGROUND
Vascular endothelial growth factor-C (VEGF-C), which contributes to lymphatic metastasis (LM) in malignant disease, is one of the most important factors involved in physical and pathological lymphangiogenesis. Some VEGF-C related factors such as sine oculis homeobox homolog (SIX) 1,
Histological and histochemical studies of stomach cancer and comparisons of characteristics of highly differentiated adenocarcinoma (24 observations) and nondifferentiated cancer (51 observations) revealed no differences in the character of the secret and in the activity of alkaline phosphatase in
The authors conducted a retrospective review of 234 bone scans of stomach cancer patients who had been diagnosed at the Seoul National University Hospital. In 106 of the 234 cases (45.3%), there were abnormal bone scan results, suggestive of bone metastases. The most common site of bone metastases
The report deals with the ultrastructural cell patterns of gastric carcinoma and electron-microscopy study of the histochemical features of cells. The histochemical features of tumor cells were compared with homologous normal epithelial cells. The localization and activity of ATP-ase, IDP-ase, acid
An unusual alkaline phosphatase (AP), named HuG-AP, was found in a newly established cell line (HuG-1) derived from a patient with stomach cancer. The enzyme was purified about 300-fold by affinity chromatography. On polyacrylamide gradient (4-30%) gel electrophoresis, the one band with the enzyme
In breast and stomach cancer the cell reactions in regional lymph nodes were studied by histochemical assaying of the T-dependent zone (acid phosphatase activity) and B-dependent zone (the activity of alkaline phosphatase, 5-nucleotidase, ATPs) and also by determining sinus histiocytosis. The
BACKGROUND
Degenerated PCR primers, designed according to the consensus tyrosine phosphatase catalytic motifs, were used in order to amplify expressed protein-tyrosine phosphatase molecules from human gastric cancer-derived cells. From such profiles, more than twenty different types of tyrosine
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