theophylline/atrophy

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Testicular atrophy and impaired spermatogenesis in rats fed high levels of the methylxanthines caffeine, theobromine, or theophylline.

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Experiments were designed to determine the effects of feeding the methylxanthines caffeine, theobromine, or theophylline to 4- to 6-week-old male rats at a dietary level of 0.5 percent for periods ranging from 14 to 75 weeks. In the first two experiments, Osborne-Mendel rats were fed the test

Testicular atrophy and impaired spermatogenesis in rats fed high levels of the methylxanthines caffeine, theobromine, or theophylline.

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Experiments were designed to determine the effects of feeding the methylxanthines caffeine, theobromine, or theophylline to 4- to 6-week-old males rats at a dietary level of 0.5 percent for periods ranging from 14 to 75 weeks. In the first two experiments, Osborne-Mendel rats were fed the test

Myocardial degeneration in mice treated with dibutyryl cyclic AMP and/or theophylline.

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Fibrinoid degeneration of myocardial fibrils was induced in BALB/c mice treated from 2 months of age with weekly injection of dibutyryl cyclic DAMP and/or theophylline. No evidence of cellular reaction or vascular occlusion was found.

The effect of theophylline on the prevention of mechanical ventilation-induced diaphragm atrophy in rats.

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BACKGROUND Movement disorders and atrophy occur in the diaphragm, the most important muscle of respiration, because of mechanical ventilation (MV). OBJECTIVE In this animal model, we aimed to evaluate the effect of intravenous theophylline administration on the prevention of mechanical

Serum theophylline during acute asthmatic attacks.

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To investigate serum theophylline levels during acute attacks of asthma, venous blood samples were taken from 41 consecutive patients. 36 had asthma and 5 suffered from chronic bronchitis. The patients were taking five different theophylline preparations. Blood samples were taken when the patients

Charcoal hemoperfusion treatment of severe theophylline toxicity.

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A 38 year old man was admitted eight hours after taking ten grams of theophylline. The plasma concentration of theophylline on admission was 732 mumol/l. In view of the patient's continuing clinical deterioration, charcoal hemoperfusion was undertaken. This led to a rapid fall in plasma theophylline

Effects of theophylline withdrawal in severe chronic obstructive pulmonary disease.

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To determine the value of theophylline in the maintenance therapy of patients with severe chronic obstructive pulmonary disease (COPD), we conducted a trial of theophylline therapy withdrawal in 38 clinically stable patients with severe COPD (FEV1 < 60 percent) predicted. Symptoms, lung function,

Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients.

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BACKGROUND Previous studies evaluating spirometric values and symptoms have shown that once daily theophylline administered in the evening produces greater stabilisation of the airway function in asthmatic patients than the prototype theophylline given twice a day. The aim of this study was to

Unilateral brain damage after prolonged hemiconvulsions in the elderly associated with theophylline administration.

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The brains of 14 elderly patients who died after status epilepticus were examined pathologically. Three of the 14 patients showed unilateral brain damage which corresponded to the side of the seizures, and the lesions were thought to be caused by seizures. In these three and two other patients, no

The usefulness of theophylline in nonasthmatic airway obstruction.

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This study evaluated the effectivness of oral bronchodilator therapy using theophylline in patients with nonreversible chronic obstructive pulmonary disease. Twelve chronic obstructive pulmonary disease patients were entered into a doubleblind crossover study using either active drug theophylline in

Failure of gastric emptying and charcoal administration in fatal sustained-release theophylline overdose: pharmacobezoar formation.

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We report the case of a fatal theophylline overdose from a sustained-release preparation in a 54-year-old woman. Initial serum theophylline concentration was 31.3 mg/L. Manifestations of mild toxicity cleared in the emergency department after treatment with gastric lavage, charcoal, and a cathartic.

Aminophylline bioavailability and the across-time stability of plasma theophylline levels.

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Three generic aminophylline products were examined and found to have equivalent bioavailability. Plasma theophylline levels were found to be reproducible in most patients (intraclass r = 0.7). There were some patients who showed wide swings in plasma theophylline levels without signs of toxicity or

Salmeterol vs theophylline: sleep and efficacy outcomes in patients with nocturnal asthma.

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OBJECTIVE To compare the efficacy, safety, and effects on sleep quality of salmeterol and extended-release theophylline in patients with nocturnal asthma. METHODS Randomized, double-blind, double-dummy, three-period crossover. METHODS Outpatients at a single center. Patients spent 1 night during

[Long-term theophylline therapy in sleep apnea--follow-up over a period of 12 months].

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Among all the sleep-related respiratory disorders, sleep apnoea is clinically the most important one because of its high incidence and potential cardiovascular sequelae. Treatment depends upon the risk profile of the individual patient; in severe cases or in risk patients nasal continuous

Improved control of asthma in the office setting. A large-scale study of once-daily evening doses of theophylline.

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A large-scale, multi-investigator open evaluation compared a once-daily regimen of controlled-release theophylline (Uniphyl tablets) with previous twice- or thrice-daily methylxanthine regimens. Three hundred asthmatic patients, 78 percent prone to nocturnal episodes during prior therapy, completed

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