theophylline/dichloromethane

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Simultaneous determination of rufloxacin and theophylline by high-performance liquid chromatography in human plasma.

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A sensitive, specific and rapid liquid chromatographic procedure to monitor rufloxacin and theophylline selectively in human plasma has been developed and validated. Plasma samples were extracted with a mixture of dichloromethane-diethyl ether. The organic layer was evaporated to dryness,

Evaluation of an aliphatic polyurethane as a microsphere matrix for sustained theophylline delivery.

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In spite of several biomedical applications of polyurethanes, very little attention has been focused on these polymers for controlled drug delivery. In this study, an aliphatic polyurethane, Tecoflex, was evaluated as a microsphere matrix for the controlled release of theophylline. Polyurethane

Membrane surface functionalization via theophylline derivative coating and streptavidin immobilization.

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Poly(vinylidene fluoride) (PVDF) and regenerated cellulose (RC) membranes were surface-modified by the adsorption of one adenosine receptor antagonist: the theophylline-oligo(ethylene glycol)-alkene derivative, Theo1. Surface modification was carried out by immersion of the membrane in a

The simultaneous determination of theophylline, theobromine and caffeine in plasma by high performance liquid chromatography.

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A high performance liquid chromatographic procedure for the stimultaneous micro-scale determination of theophylline, theobromine and caffeine in plasma is described. After a single dichloromethane extraction of 0.5--0.2 ml of acidified plasma, the evaporated residue is chromatographed on a

Glutaraldehyde cross-linked bovine casein microspheres as a matrix for the controlled release of theophylline: in-vitro studies.

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A controlled release dosage form of theophylline in the form of microspheres using the milk protein casein as the matrix is described. Glutaraldehyde cross-linking of an aqueous alkaline solution of the protein containing the drug, dispersed in a mixture of dichloromethane/hexane having ca. 1% of an

The assay and absorption kinetics of oral theophylline-7-acetic acid in the human.

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A sensitive and specific method for the estimation of theophylline-7-acetic acid in plasma by high performance liquid chromatography is described. Acidified plasma is extracted with chloroform-n-butanol (85: 15), back extracted with phosphate buffer (0.5 mmol-1, pH 6.5), and finally the acidified

Design of a microporous controlled delivery system for theophylline tablets.

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The aim of present work was to develop a microporous-controlled delivery system for theophylline via coating a blend of PCL and PEG on the surface of tablets, where PCL was the major component of film coating material and PEG was acted as a leachable pore-forming agent when contacting with an

Simultaneous assay of fluoroquinolones and theophylline in plasma by high-performance liquid chromatography.

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A sensitive and selective reversed-phase high-performance liquid chromatographic method for the determination of theophylline in plasma simultaneously with either ciprofloxacin, enoxacin or norfloxacin has been developed. It involves extraction of plasma with chloroform-isopropanol or

[Development of syringe-type off line pre-column and simultaneous quantitation of four xanthine derivatives (caffeine, theobromine, theophylline and paraxanthine) in serum].

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A new syringe-type minicolumn, called Extrashot-Silica (EXS-Silica), containing diatomaceous earth granules was described. The EXS-Silica differs from the conventional pretreatment column. Using the EXS-Silica we can execute the simultaneous extraction-injection to HPLC, column. Therefore, an

High-performance liquid chromatographic analysis of theophylline in serum and its use in therapeutic drug monitoring.

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A rapid, highly sensitive high-performance liquid chromatographic method has been developed for the determination of theophylline in serum using beta-hydroxyethyltheophylline as an internal standard (IS). Theophylline and IS were extracted from serum using a mixture of dichloromethane: isopropanol

[Determination of plasma theophylline in the newborn by high resolution gas chromatography and specific detection (author's transl)].

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The authors describe a micromethod for the determination of blood concentration of theophylline in premature newborn infants. The method includes the specificity of separation in gas phase chromatography on a glass capillary column, and the sensitivity of thermo-ionic detection. After addition of

Theophylline-ethylcellulose microparticles: screening of the process and formulation variables for preparation of sustained release particles.

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OBJECTIVE The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. METHODS Microspheres were prepared by water-in-oil-in-oil (W/O1/O2) emulsion-solvent

Preparation of double-encapsulated microcapsules for mitigating drug loss and extending release.

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The double-encapsulated microcapsules were prepared by the non-solvent addition, phase-separation method to form core material and, encapsulated with the O/W emulsion non-solvent addition method to increase drug loading and regulate drug release rate. The drug used was theophylline, which is

Determination of caffeine in coffee products by dynamic complexation with 3,4-dimethoxycinnamate and separation by CZE.

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A method based on the formation of pi-complexes with chlorogenate-like species was proposed for the determination of caffeine in regular (nondecaffeinated) and decaffeinated coffee. Both caffeate and 3,4-dimethoxycinnamate were able to transform caffeine--a neutral species in aqueous solutions--into

Rapid and sensitive gas-chromatographic determination of caffeine in blood plasma, saliva, and xanthine beverages.

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A gas chromatographic procedure is reported for the determination of caffeine in plasma, saliva, and xanthine beverages. Using a 75 cm column packed with OV-17, nitrogen-sensitive detection, and 1 ml samples, a suitable limit of analysis (coefficient of variation (CV) = 10.2%) of 50 ng/ml was

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