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proteinase inhibitor/hemorrhage

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Leht 1 alates 175 tulemused
A pharmacokinetic model is described for testing of polymorphonuclear leukocyte (PMN) elastase inhibitors administered by intratracheal or aerosol dosing of hamsters. Acute lung injury, measured as hemorrhage occurring within hours after intratracheal instillation of human PMN elastase, correlated
In patients with severe head injury or multiple trauma a multitude of inflammatory mediators are released. As in cerebral bleeding, elevations of body temperature can be observed even in the absence of bacterial infections. In order to evaluate the diagnostic significance of plasma elastase levels

Alpha-1-proteinase inhibitor and pulmonary haemorrhage in systemic vasculitis.

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Alpha-1-proteinase inhibitor phenotypes and levels were examined in 40 antineutrophil cytoplasmic antibody positive cases of systemic vasculitis. An excess of PiZ and PiS alleles were associated with the development of pulmonary haemorrhage and alpha-1-proteinase inhibitor levels were lower in the

The role of alpha 1-proteinase inhibitor in semisoluble glucan induced resistance to hemorrhage.

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The present study was undertaken to evaluate the mechanism of protective effect of semisoluble beta-1,3-carboxymethylglucan (CMG) during acute massive hemorrhage. CBA mice were injected i.v. with glucan (25 mg/kg) 24 h prior to hemorrhage (50% of blood circulating volume). Survival data indicated
The present study was undertaken to evaluate the mechanism of protective effect of semisoluble alpha-1,3-carboxymethylglucan during massive acute hemorrhage. CBA mice were injected i.v. with glucan (25 mg/kg) 24 h prior to hemorrhage (50% of blood circulating volume). Survival data indicated that
We investigated the relationship between the levels of granulocyte elastase alpha 1-proteinase inhibitor complex (E-alpha 1-PI) in plasma and severe intraventricular hemorrhage (IVH) in very low birthweight infants. The concentrations of E-alpha 1-PI and the ratio of the concentrations of E-alpha

Hemorrhage induced by intrauterine devices: control by local proteinase inhibition.

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The intrauterine application of proteinase inhibitors, tranexaminc acid and the pancreatic trypsin inhibitor (Trasylol), reduces or eliminates menorrhagia and intermenstrual bleeding (spotting) produced by an intrauterine device (IUD). A decrease in pain and vaginal (cervical) discharge is also

Acute hemorrhagic pancreatic necrosis in mice. Effects of proteinase inhibitors on its induction.

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An acute hemorrhagic pancreatitis with fat necrosis (AHPN) was induced in female mice fed a choline-deficient diet containing 0.5% DL-ethionine. The effect of various proteinase inhibitors on the induction of the pancreatitis was evaluated using three parameters, the mortality of the animals, the

Effect of the proteinase inhibitor aprotinin in the management of hemorrhagic shock in the dog.

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Aprotinin, a proteinase inhibitor, was evaluated as a pharmacologic aid in dogs subjected to lethal hemorrhagic shock. Survival time, hemodynamic changes, and plasma enzyme analysis were measured as criteria for drug effects. Mixed-breed dogs (n = 14) were divided into 2 groups of 7 each: nontreated
The isolation and characterization of six human cysteine proteinase inhibitors is reported. Their distribution in human biological fluids is also described and discussed with respect to physiological function. Studies on kininogen and cystatin C with respect to structure-function relationships and,

[Kinin system components and blood serum proteinase inhibitors in hemorrhagic fever with renal syndrome].

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In polyuric period of hemorrhagic fever with renal syndrome a distinct activation of the kinin system was observed in blood serum of patients; it was manifested as an increase in spontaneous BAEE-esterase and kallikreine activities as well as a decrease in kininogen content. Content of inhibitors of
The parameters of proteinase-inhibitor balance and lipid metabolism were studied in the blood of patients with proliferative diabetic retinopathy. Metabolic disorders in patients with proliferative diabetic retinopathy with hemophthalmia are characterized by a notable increase in the activities of
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