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hemolysis/− nicotine
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Effects of cigarette smoke, nicotine and cotinine on red blood cell hemolysis and their -SH capacity.
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BACKGROUND
Smoking is a leading cause of premature death. Red blood cell (RBC) membrane lipids are rich in polyunsaturated fatty acids; therefore, the effect of oxygen on RBC membranes is more prominent than on other body tissues. The attachment of peroxidants to RBC membranes can result in
Nicotine alkaloids as antioxidant and potential protective agents against in vitro oxidative haemolysis.
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The capacity of eleven nicotine alkaloids to reduce oxidative stress was investigated. In order to provide a structure-activity relationships analysis, new nicotine derivatives with a substituent introduced into the pyrrolidine ring were synthesized and investigated together with nicotine and its
Effect of Tobacco Smoking on Outcomes after Left Ventricular Assist Device Implantation.
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Despite the well-established correlation between tobacco use and cardiovascular disease, little is known about postoperative outcomes following left ventricular assist device (LVAD) implantation. We aimed to elucidate the effect of tobacco smoking on post-LVAD implant outcomes. Patients who received
Outcomes in an obstetrical population with hereditary thrombophilia and high tobacco use.
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OBJECTIVE
The purpose of this study was to examine birth outcomes in women treated or untreated for thrombophilia during pregnancies affected or not by tobacco exposure.
METHODS
This was a retrospective cohort study of consecutive women from a single maternal fetal medicine clinic who delivered
The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants.
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Rapid production of influenza vaccine antigen is an important challenge when a new pandemic occurs. Production of recombinant antigens in plants is a quick, cost effective and up scalable new strategy for influenza vaccine production. In this study, we have characterized a recombinant influenza
[The erythrocyte composition of the peripheral blood in tobacco smokers].
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Data of cytometry and acid erythrography were evaluated in 60 tobacco smokers and 30 non-smoking healthy persons depending on length of smoking. Tobacco smoking was found to effect blood erythrocytes. Five-year smoking resulted in an increase of macrocytes, young resistant cells. Toxic signs were
Synthesis and haemolytic activity of novel salts made of nicotine alkaloids and bile acids.
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A series of novel salts made of nicotine alkaloids and bile acids were synthesized and their haemolytic activity was examined in vitro using human erythrocytes. All compounds were characterized by spectroscopic methods. The novel salts show membrane-perturbing properties inducing the erythrocyte
Short term bioassay of cigarettes containing Cytrel tobacco supplement.
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The toxicity of smoke from cigarettes containing tobacco, Cytrel tobacco supplement, or mixtures of the 2 materials, was investigated using 6 short term test methods. The tests used were rat trachea organ culture and mouse skin thickening tests, which may provide information on carcinogenicity, a
Biodistribution, pharmacokinetics, and blood compatibility of native and PEGylated tobacco mosaic virus nano-rods and -spheres in mice.
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Understanding the pharmacokinetics, blood compatibility, biodistribution and clearance properties of nanoparticles is of great importance to their translation to clinical application. In this paper we report the biodistribution and pharmacokinetic properties of tobacco mosaic virus (TMV) in the
Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers.
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Tobacco smoke is phototoxic.
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BACKGROUND
Both cigarette smoke and ultraviolet (UV) radiation are known to cause changes of the skin which can be regarded as premature ageing.
OBJECTIVE
To assess the theory that the effects of these two exposures could be linked by a phototoxic action of cigarette smoke.
METHODS
A photohaemolysis
In vitro hemolysis of autologous erythrocytes caused by immune murine spleen cells and spherules of the fungus Coccidioides immitis.
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This communication describes an in vitro system wherein mouse erythrocytes are lysed in the presence of spherules of the fungus Coccidioides immitis and spleen cells from syngeneic mice immunized with a variety of antigens. The antigens include: tobacco mosaic virus in complete Freund's adjuvant
Causes of Preanalytical Interferences on Laboratory Immunoassays - A Critical Review.
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The immunoassays methods need avoiding interferences that can influence result interpretation. Main sources of interference arise from either patient status, preparation and physiology or laboratory process and procedures. The aim of this non-systematic critical review is to highlight the
Biological activities of pseudomycin A, a lipodepsinonapeptide from Pseudomonas syringae MSU 16H.
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Similarly to other Pseudomonas lipodepsinonapeptides, pseudomycin A inhibits proton extrusion from maize roots, promotes closure of stomata in Vicia faba, necrosis of tobacco leaves, haemolysis of human erythrocytes, affects H(+)-ATPase activity and proton translocation in plasma membrane vesicles,
Peptidotriazoles with antimicrobial activity against bacterial and fungal plant pathogens.
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We designed and prepared peptidotriazoles based on the antimicrobial peptide BP100 (LysLysLeuPheLysLysIleLeuLysTyrLeu-NH(2)) by introducing a triazole ring in the peptide backbone or onto the side chain of a selected residue. These compounds were screened for their in vitro growth inhibition of
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